6-(叔-丁基二甲基硅烷基氧基)-1-己炔合成路线 （共 22 条）
反应条件
1: 99 percent / n-BuLi / tetrahydrofuran / 4 h / -78 - 20 °C 2: 99 percent / pyridinium p-toluene sulfonate / CH2Cl2 3: 97 percent / TBAF / tetrahydrofuran / 0 °C View Scheme
参考文献
Linb, Chi-Fong; Hwanga, Martin; Kuo, Yao-Haur; Wu, Ming-Jung
Journal of the Chinese Chemical Society, 2007 , vol. 54, # 2 p. 525 - 532
反应条件
triethylamine hydrofluoric acid in tetrahydrofuran T=50°C; 19 h; var. reag.: (n-Bu)4N(1+)*F(1-);
参考文献
Nystroem, Jan-E.; McCanna, Terrence D.; Helquist, Paul; Iyer, Ramnath S.
Tetrahedron Letters, 1985 , vol. 26, # 44 p. 5393 - 5396
反应条件
1: 1) Cp2Zr(H)Cl, 2) NIS / 1) toluene, 30h, 25 deg C, 2) 62h 3: 80 percent / 5percent HCl / tetrahydrofuran / 216 h / 25 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 56, # 8 p. 2883 - 2894
反应条件
1: 1) n-BuLi / 1) ether, -50 deg C to 25 deg C, 1.5 h, 2) -78 deg C 2: 80 percent / PDC 3: 90 percent / 2 percent HCl / methanol / 3 h / 25 °C View Scheme
参考文献
Sun, Wei-Chuan; Ng, Chi-Shing; Prestwich, Glenn D.
Journal of Organic Chemistry, 1992 , vol. 57, # 1 p. 132 - 137
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane
20 h; Ambient temperature;
参考文献
Maleczka Jr., Robert E.; Ghosh, Banibrata; Gallagher, William P.; Baker, Aaron J.; Muchnij, Jill A.; Szymanski, Amy L.
Tetrahedron, 2013 , vol. 69, # 19 p. 4000 - 4008
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in water; acetonitrile
T=60°C; 6 h;
参考文献
Yeom, Chang-Eun; Mi, Jeong Kim; Choi, Whail; Kim, B. Moon
Synlett, 2008 , # 4 p. 565 - 568
反应条件
ethylenediamine in dimethyl sulfoxide; pentane
T=25°C; 7 h;
参考文献
Nystroem, Jan-Erik; McCanna, Terrence D.; Helquist, Paul; Amouroux, Roger
Synthesis, 1988 , # 1 p. 56 - 58
反应条件
in dimethyl sulfoxide; pentane
T=25°C; 4 h;
参考文献
Nystroem, Jan-E.; McCanna, Terrence D.; Helquist, Paul; Iyer, Ramnath S.
Tetrahedron Letters, 1985 , vol. 26, # 44 p. 5393 - 5396
反应条件
1: 89 percent / NaI / acetonitrile / 10 h / 55 °C
2: 74 percent / ethylenediamine / pentane; dimethylsulfoxide / 7 h / 25 °C
View Scheme
参考文献
Nystroem, Jan-Erik; McCanna, Terrence D.; Helquist, Paul; Amouroux, Roger
Synthesis, 1988 , # 1 p. 56 - 58
反应条件
1: 1.) 4.55 M n-BuLi/hexane, Et2Al/toluene / 1.) THF; 2.) (CH2Cl)2, THF, r.t., 15 min, then r.t., 3 h
2: 99 percent / H2 / Lindlar's catalyst / hexane
View Scheme
参考文献
Trost, Barry M.; Martin, Steven J.
Journal of the American Chemical Society, 1984 , vol. 106, # 15 p. 4263 - 4265
