(E)-3-(吡啶-2基)丙烯酸合成路线 （共 7 条）
反应条件
piperidine; pyridine Yield given;
参考文献
European Journal of Medicinal Chemistry, , vol. 24, p. 65 - 72
反应条件
1: conc. H2SO4 2: H2 / 5percent Pd/C / ethanol / 45 °C View Scheme
参考文献
Brown, Thomas H.; Blakemore, Robert C.; Blurton, Peter; Durant, Graham J.; Ganellin, C. Robin; et al.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 65 - 72
参考文献
Brown, Thomas H.; Blakemore, Robert C.; Blurton, Peter; Durant, Graham J.; Ganellin, C. Robin; et al.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 65 - 72
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate 24 h;
参考文献
Kempf, Dale J.; Codacovi, Lynnmarie; Wang, Xiu Chun; Kohlbrenner, William E.; Wideburg, Norman E.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 3 p. 320 - 330
反应条件
1: With sulfuric acid
Reflux;
2: With sodium hydrogencarbonate in methanol; water
T=20°C;
参考文献
GRUENENTHAL GmbH
Patent: US2009/253669 A1, 2009 ;
Location in patent: Page/Page column 45 ;
US 20090253669 A1
反应条件
1: conc. H2SO4
2: H2 / 5percent Pd/C / ethanol / 45 °C
3: sodium wire / diethyl ether / 18 h / Ambient temperature
4: ethanol / 7 h / Heating
5: 69 percent / NaOH / H2O; ethanol / 60 °C
6: 36 percent / 2.) ethanolic hydrogen chloride / 5 h / 145 - 150 °C
View Scheme
参考文献
Brown, Thomas H.; Blakemore, Robert C.; Blurton, Peter; Durant, Graham J.; Ganellin, C. Robin; et al.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 65 - 72
反应条件
1: conc. H2SO4
2: H2 / 5percent Pd/C / ethanol / 45 °C
3: sodium wire / diethyl ether / 18 h / Ambient temperature
4: ethanol / 7 h / Heating
5: 69 percent / NaOH / H2O; ethanol / 60 °C
6: 45 percent / 2.) 2 N HBr / 5 h / 145 - 150 °C
View Scheme
参考文献
Brown, Thomas H.; Blakemore, Robert C.; Blurton, Peter; Durant, Graham J.; Ganellin, C. Robin; et al.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 65 - 72
