1-羟基-4-甲氧基蒽醌合成路线 （共 34 条）
反应条件
1: 1.) lithium di-isopropylamide, 2.) air / 1.) THF, -70 - -60 deg C, 2.) THF, 20 deg C, 22 h
2: 98 percent / conc. hydrochloric acid / tetrahydrofuran / 15 h / Ambient temperature
View Scheme
参考文献
Dodsworth, David J.; Calcagno, Maria-Pia; Ehrmann, E. Ursula; Devadas, Bhatt; Sammes, Peter G.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 2120 - 2124
反应条件
1: 82 percent / Na2CO3 / 1,2-dichloro-benzene / 12 h / Heating
2: 1.) BF3-Et2O, 2.) bromine
3: 46 percent / 2,3-dichloro-5,6-dicyanobenzoquinone / toluene / 6 h / Heating
View Scheme
参考文献
Preston, Peter N.; Will, Stephen G.; Winwick Thomas; Morley, John O.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 5 p. 1001 - 1007
反应条件
1: 1.) BF3-Et2O, 2.) bromine
2: 46 percent / 2,3-dichloro-5,6-dicyanobenzoquinone / toluene / 6 h / Heating
View Scheme
参考文献
Preston, Peter N.; Will, Stephen G.; Winwick Thomas; Morley, John O.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 5 p. 1001 - 1007
反应条件
1: AlCl3, aluminium chloride; sodium chloride / 0.75 h / 165 - 170 °C
2: potassium carbonate / acetone / 6 h / |Reflux
View Scheme
参考文献
Saha, Koushik; Lam, Kok Wai; Abas, Faridah; Sazali Hamzah; Stanslas, Johnson; Hui, Lim Siang; Lajis, Nordin H.
Medicinal Chemistry Research, 2013 , vol. 22, # 5 p. 2093 - 2104
反应条件
sulfuric acid; sodium acetate
参考文献
Cameron, Donald W.; Feutrill, Geoffrey I.; McKay, Peter G.
Tetrahedron Letters, 1981 , vol. 22, p. 701 - 702
反应条件
lithium diisopropyl amide
1.) THF, - 78 deg C, 5 min, 2.) THF, -78 deg C, 30 min; Yield given. Multistep reaction;
参考文献
Mitchell, Anthony S.; Russell, Richard A.
Tetrahedron, 1997 , vol. 53, # 12 p. 4387 - 4410
反应条件
methanol; sodium methylate
参考文献
Waldmann
Journal fuer Praktische Chemie (Leipzig), 1931 , vol. <2>130, p. 92,98
反应条件
1: AlCl3; NaCl / 200 - 220 °C
2: 1.4-dichloro-benzene; K2CO3 / 170 °C
3: methanol; sodium methylate
View Scheme
参考文献
Waldmann
Journal fuer Praktische Chemie (Leipzig), 1931 , vol. <2>130, p. 92,98
反应条件
1: AlCl3; NaCl / 200 - 220 °C
2: 1.4-dichloro-benzene; K2CO3 / 170 °C
3: methanol; sodium methylate
View Scheme
参考文献
Waldmann
Journal fuer Praktische Chemie (Leipzig), 1931 , vol. <2>130, p. 92,98
反应条件
air; lithium diisopropyl amide
1.) THF, -70 - -60 deg C, 2.) THF, 20 deg C, 22 h; Yield given. Multistep reaction;
参考文献
Dodsworth, David J.; Calcagno, Maria-Pia; Ehrmann, E. Ursula; Devadas, Bhatt; Sammes, Peter G.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 2120 - 2124
