3-(1-哌啶甲基)苯酚合成路线 （共 17 条）
反应条件
1: potassium carbonate 2: thionyl chloride View Scheme
参考文献
Hough; Nalwalk; Li; Leurs; Menge; Timmerman; Carlile; Cioffi; Wentland
Journal of Pharmacology and Experimental Therapeutics, 1997 , vol. 283, # 3 p. 1534 - 1543
反应条件
sodium hydroxide in methanol 4 h; Heating;
参考文献
Ogawa; Yoshida; Aratani; Koshinaka; Kato; Ito
Chemical and pharmaceutical bulletin, 1988 , vol. 36, # 8 p. 2955 - 2967
反应条件
sodium hydride 1.) DMF, RT, 1 h, 2.) DMF, RT, 3 h; Yield given. Multistep reaction;
参考文献
Miyashita; Matsumoto; Matsukubo; Iinuma; Taga; Sekiguchi; Hamada; Okamura; Nishino
Journal of Medicinal Chemistry, 1992 , vol. 35, # 13 p. 2446 - 2451
反应条件
sodium hydride
1.) DMF, RT, 18 h, 2.) DMF, 50 deg C, 3,5 h; Multistep reaction;
参考文献
Glaxo Group Limited
Patent: US4318913 A1, 1982 ;
US 4318913 A
参考文献
Zyma SA
Patent: US5212187 A1, 1993 ;
US 5212187 A
反应条件
2: hydrazine hydrate / ethanol / Heating
View Scheme
参考文献
Mohr; Buschauer; Schunack
Archiv der Pharmazie, 1988 , vol. 321, # 4 p. 221 - 227
参考文献
Hough; Nalwalk; Li; Leurs; Menge; Timmerman; Carlile; Cioffi; Wentland
Journal of Pharmacology and Experimental Therapeutics, 1997 , vol. 283, # 3 p. 1534 - 1543
