3,5-二溴噻吩-2-甲酸合成路线 （共 10 条）
反应条件
1: 2,3,5-tribromothiophene With n-butyllithium in diethyl ether; hexane T=-78°C; 2: carbon dioxide in diethyl ether; hexane Further stages.;
参考文献
Pereira, Raquel; Furst, Audrey; Iglesias, Beatriz; Germain, Pierre; Gronemeyer, Hinrich; De Lera, Angel R.
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 24 p. 4514 - 4525
反应条件
n-butyllithium; diisopropylamine in tetrahydrofuran; hexane 1.) -78 deg C, 15 min, 2.) -78 deg C -> 0 deg C;
参考文献
Hawkins, David W.; Iddon, Brian; Longthorne, Darren S.; Rosyk, Peter J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 19 p. 2735 - 2744
反应条件
n-butyllithium; diethyl ether anschliessend Behandeln mit festem Kohlendioxid;
参考文献
Arkiv foer Kemi, , vol. 11, p. 317,322
反应条件
n-butyllithium; diethyl ether anschliessend Behandeln mit festem Kohlendioxid;
参考文献
Acta Chemica Scandinavica (1947-1973), , vol. 10, p. 1020,1021
Arkiv foer Kemi, , vol. 11, p. 317,321
反应条件
bromine; acetic acid
参考文献
Arkiv foer Kemi, , vol. 11, p. 317,322
反应条件
methyl bromide; diethyl ether; magnesium Behandeln der Reaktionsloesung mit Kohlendioxid;
参考文献
Justus Liebigs Annalen der Chemie, , vol. 512, p. 136,156
参考文献
Arkiv foer Kemi, , vol. 11, p. 317,322
参考文献
Arkiv foer Kemi, , vol. 11, p. 317,322
反应条件
1: SOCl2 / 0.25 h / Heating
2: 1 h / Heating
View Scheme
参考文献
Aitken, R. Alan; Bibby, Michael C.; Bielefeldt, Florian; Double, John A.; Laws, Andrea L.; Mathieu, Anne-Laure; Ritchie, Robert B.; Wilson, David W. J.
Archiv der Pharmazie, 1998 , vol. 331, # 12 p. 405 - 411
反应条件
sulfuric acid
6 h; Heating;
参考文献
Pereira, Raquel; Furst, Audrey; Iglesias, Beatriz; Germain, Pierre; Gronemeyer, Hinrich; De Lera, Angel R.
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 24 p. 4514 - 4525
