反应条件
1.1: triphenylphosphine; sodium iodide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 3 h / 20 - 85 °C / |Industrial scale 2.1: iodine; potassium carbonate / tetrahydrofuran / 4 h / 65 - 70 °C / |Industrial scale 3.1: lithium hydroxide hydrate; water / methanol / 3 h / 45 - 50 °C / |Industrial scale 3.2: 1.5 h / 0 - 25 °C / pH 2 - 3 / |Industrial scale 4.1: sodium tetrahydroborate; hydrogen / tetrahydrofuran / 1 h / 65 - 75 °C 5.1: potassium tert-butylate / tetrahydrofuran / 1 h View Scheme
参考文献
DAEWOONG PHARMACEUTICAL CO., LTD.; MEDIFRON DBT CO., LTD.; CHOI, Soo Jin; LEE, Byung Goo; YOON, Hee Kyoon; LIM, Young Mook; LEE, Joon Hwan; PARK, Sung Woo
Patent: WO2014/7554 A1, 2014 ;
