3-(1-哌啶基)苯丙酮盐酸盐合成路线 （共 25 条）
反应条件
sodium carbonate in toluene
参考文献
SANWA KAGAKU KENKYUSHO CO., LTD.
Patent: EP558321 A1, 1993 ;
反应条件
1: in tetrahydrofuran T=20°C; Substitution; 6 h; 2: With water in tetrahydrofuran T=20°C; Michael reaction; 0.25 h; Further stages.;
参考文献
Gomtsyan, Arthur
Organic Letters, 2000 , vol. 2, # 1 p. 11 - 13
反应条件
1: bromobenzene With magnesium in tetrahydrofuran 1 h; Heating; 2: N-methoxy-N-methyl-3-piperidin-1-yl-propionamide in tetrahydrofuran T=0°C;
参考文献
Selvamurugan; Aidhen
Synthesis, 2001 , # 15 p. 2239 - 2246
反应条件
in methanol T=40°C; P=6000480 Torr; 24 h;
参考文献
Matsumoto, Kiyoshi
Angewandte Chemie, 1982 , vol. 94, # 12 p. 937
反应条件
1: N-Methoxy-N-methyl-benzamide; vinyl-magnesium bromide in tetrahydrofuran T=0 - 20°C; 1.16667 h; 2: morpholine in tetrahydrofuran; water T=20°C; 0.333333 h; Further stages.;
参考文献
Gomtsyan; Koenig; Lee
Journal of Organic Chemistry, 2001 , vol. 66, # 10 p. 3613 - 3616
反应条件
acetic acid in acetonitrile Mannich reaction; 14 h; Reflux;
参考文献
Guo, Yuan; An, Jing; Lu, Zhenhuan; Peng, Mengjiao
Chinese Journal of Chemistry, 2012 , vol. 30, # 7 p. 1561 - 1564
反应条件
in tetrahydrofuran T=25°C; Yields of byproduct given;
参考文献
Katritzky, Alan R.; Harris, Philip A.
Tetrahedron, 1990 , vol. 46, # 3 p. 987 - 996
反应条件
in ethanol 1 h; Heating;
参考文献
Schmidt, Axel M.; Eilbracht, Peter
Journal of Organic Chemistry, 2005 , vol. 70, # 14 p. 5528 - 5535
反应条件
1: conc. HCl / ethanol / 4 h / Heating 2: ethanol; benzene / 10 h / Heating View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 31, # 4 p. 281 - 290
反应条件
1: 1.) MeLi, 2.) TiCl4 / 1.) CH2Cl2, THF; 2.) CH2Cl2, -78 deg C, 1 h 2: potassium fluoride / CH2Cl2 / 16 h / Heating View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 61, # 3 p. 735 - 740
