4-氟-DL-alpha-苯甘氨酸合成路线 （共 18 条）
反应条件
1: With sodium hydroxide in water; acetone T=20°C; 3 h; 2: With hydrogenchloride in water pH=1;
参考文献
CHIESI FARMACEUTICI S.p.A.
Patent: US2012/134934 A1, 2012 ;
Location in patent: Page/Page column 29 ;
反应条件
N-phenylaminoacetic acid; (+)-10-camphorsulfonic acid in water T=20 - 100°C; racemat resolution; Title compound not separated from byproducts;
参考文献
Yasukawa, Kazuyuki; Asano, Yasuhisa
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 17 p. 3327 - 3332
参考文献
Soloshonok, V. A.; Galaev, I. Yu.; Shvyadas, V. K.; Kozlova, E. V.; Kotik, N. V.; et al.
Russian Journal of Bioorganic Chemistry, 1993 , vol. 19, # 4 p. 228 - 232
Bioorganicheskaya Khimiya, 1993 , vol. 19, # 4 p. 467 - 473
反应条件
N-phenylaminoacetic acid; (+)-10-camphorsulfonic acid in water T=20 - 100°C; racemat resolution; Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 11, # 6 p. 1343 - 1351
反应条件
1: 75 percent / NaHCO3 / H2O; acetone / 3 h / -5 - 20 °C 2: 91 percent / H2O / aminoacylase from Streptoverticillium olivoreticuli View Scheme
参考文献
Russian Journal of Bioorganic Chemistry, , vol. 19, # 4 p. 228 - 232
Bioorganicheskaya Khimiya, , vol. 19, # 4 p. 467 - 473
反应条件
hydrogenchloride T=130°C; Yields of byproduct given;
参考文献
Pharmazie, , vol. 44, # 8 p. 540 - 542
反应条件
sodium hydrogencarbonate in water; acetone T=-5 - 20°C; 3 h;
参考文献
Soloshonok, V. A.; Galaev, I. Yu.; Shvyadas, V. K.; Kozlova, E. V.; Kotik, N. V.; et al.
Russian Journal of Bioorganic Chemistry, 1993 , vol. 19, # 4 p. 228 - 232
Bioorganicheskaya Khimiya, 1993 , vol. 19, # 4 p. 467 - 473
反应条件
hydrogenchloride
T=0 - 20°C; 18 h;
参考文献
MERCK and CO., INC.
Patent: WO2006/78554 A2, 2006 ;
Location in patent: Page/Page column 50 ;
WO 2006/078554 A2
