2-硝基-10H-吖啶-9-酮合成路线 （共 25 条）
反应条件
1: methyl iodide; ethanol 2: SnCl2; aqueous HCl 3: aqueous hydrochloric acid / 220 °C / im geschlossenen Gefaess View Scheme
参考文献
Lehmstedt; Hundertmark
Chemische Berichte, 1931 , vol. 64, p. 2386,2391
反应条件
hydrogenchloride; tin(ll) chloride
参考文献
Ferencz, Laszlo; Farcasan, Valer; Silberg, Ioan A.
Revue Roumaine de Chimie, 2003 , vol. 48, # 10 p. 801 - 811
反应条件
hydrogenchloride in ethanol; water
Friedel Crafts acylation; 1 h; Reflux;
参考文献
Marques, Emerson F.; Bueno, Mauro A.; Duarte, Patricia D.; Silva, Larissa R.S.P.; Martinelli, Ariani M.; Dos Santos, Caio Y.; Severino, Richele P.; Broemme, Dieter; Vieira, Paulo C.; Correa, Arlene G.
European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 10 - 21
反应条件
nitric acid; acetic acid
T=50°C;
参考文献
Gao, Chunmei; Liu, Feng; Luan, Xudong; Tan, Chunyan; Liu, Hongxia; Xie, Yonghua; Jin, Yibao; Jiang, Yuyang
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 21 p. 7507 - 7514
反应条件
trichlorophosphate
0.5 h;
参考文献
Ferencz, Laszlo; Farcasan, Valer; Silberg, Ioan A.
Revue Roumaine de Chimie, 2003 , vol. 48, # 10 p. 801 - 811
反应条件
hydrogenchloride; sodium nitrite in ethanol
T=70°C; 0.5 h;
参考文献
Horowska, Barbara; Ledochowski, Andrzej; Potrykus, Andrzej
Polish Journal of Chemistry, 1984 , vol. 58, # 4/5/6 p. 603 - 605
反应条件
nitric acid in acetic acid
T=50°C; 7 h; Product distributionMechanism;
参考文献
Daszkiewicz, Zdzislaw; Kyziol, Janusz B.
Journal fuer Praktische Chemie (Leipzig), 1988 , vol. 330, # 1 p. 44 - 50
反应条件
1: 60 percent / HNO3, conc. H2SO4 / a) 20 deg C, 0.5 h, b) 80 deg C, 0.5 h
2: 80 percent / Na2S*9H2O / pyridine / 4 h / Ambient temperature
3: conc. HCl, sodium nitrite / ethanol / 0.5 h / 70 °C
View Scheme
参考文献
Horowska, Barbara; Ledochowski, Andrzej; Potrykus, Andrzej
Polish Journal of Chemistry, 1984 , vol. 58, # 4/5/6 p. 603 - 605
反应条件
1: 80 percent / Na2S*9H2O / pyridine / 4 h / Ambient temperature
2: conc. HCl, sodium nitrite / ethanol / 0.5 h / 70 °C
View Scheme
参考文献
Horowska, Barbara; Ledochowski, Andrzej; Potrykus, Andrzej
Polish Journal of Chemistry, 1984 , vol. 58, # 4/5/6 p. 603 - 605
反应条件
1: copper(l) iodide; potassium carbonate; L-proline / water; N,N-dimethyl-formamide / 1 h / 160 °C / Microwave irradiation
2: trichlorophosphate / 2 h / Inert atmosphere; Reflux
3: hydrogenchloride / ethanol; water / 1 h / Reflux
View Scheme
参考文献
Marques, Emerson F.; Bueno, Mauro A.; Duarte, Patricia D.; Silva, Larissa R.S.P.; Martinelli, Ariani M.; Dos Santos, Caio Y.; Severino, Richele P.; Broemme, Dieter; Vieira, Paulo C.; Correa, Arlene G.
European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 10 - 21
