4’-甲氧基联苯基-4-羧酸合成路线 （共 44 条）
反应条件
potassium carbonate; dichlorobis(4-pyridinaldoxime)palladium(II) in water Suzuki reaction; 0.666667 h; Heating;
参考文献
Bernini, Roberta; Cacchi, Sandro; Fabrizi, Giancarlo; Forte, Giovanni; Petrucci, Francesco; Prastaro, Alessandro; Niembro, Sandra; Shafir, Alexandr; Vallribera, Adelina
Green Chemistry, 2010 , vol. 12, # 1 p. 150 - 158
反应条件
sodium hydroxide; bromine in 1,4-dioxane; water T=0°C; 3 h;
参考文献
Boehringer Ingelheim International GmbH
Patent: US2004/242572 A1, 2004 ;
Location in patent: Page/Page column 57 ;
反应条件
potassium carbonate; palladium dichloride in PEG400; water T=20°C; Suzuki-Miyaura coupling; 0.133333 h; Air atmosphere;
参考文献
Liu, Shiwen; Lv, Meiyun; Xiao, Daoan; Li, Xiaogang; Zhou, Xiuling; Guo, Mengping
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 25 p. 4511 - 4516
反应条件
sodium hydroxide in tetrahydrofuran
参考文献
Wyeth
Patent: US2003/18024 A1, 2003 ;
反应条件
1: With sodium hydroxide; water in tetrahydrofuran T=20°C; 16.5 h; Heating / reflux; 2: With hydrogenchloride in tetrahydrofuran; water
参考文献
WYETH
Patent: WO2005/30702 A1, 2005 ;
Location in patent: Page/Page column 60 ;
反应条件
hydrogenchloride; bromine in water
参考文献
Societe d'Expansion Scientifique Expansia
Patent: US6160157 A1, 2000 ;
反应条件
potassium fluoride; trifuran-2-yl-phosphane; palladium diacetate in N,N-dimethyl-formamide T=120°C; 44 h;
参考文献
Homsi, Fadi; Hosoi, Kazushi; Nozaki, Kyoko; Hiyama, Tamejiro
Journal of Organometallic Chemistry, 2001 , vol. 624, # 1-2 p. 208 - 216
反应条件
tetrabutyl ammonium fluoride; tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=80°C; 30 h;
参考文献
Homsi, Fadi; Nozaki, Kyoko; Hiyama, Tamejiro
Tetrahedron Letters, 2000 , vol. 41, # 31 p. 5869 - 5872
反应条件
sodium carbonate in water T=100°C; Suzuki-Miyaura reaction;
参考文献
Wei, Jun-Fa; Jiao, Jiao; Feng, Jin-Juan; Lv, Jing; Zhang, Xi-Ru; Shi, Xian-Ying; Chen, Zhan-Guo
Journal of Organic Chemistry, 2009 , vol. 74, # 16 p. 6283 - 6286
反应条件
1: 4-methoxyphenyl magnesium bromide With titanium tetraethoxide in tetrahydrofuran T=20°C; 0.5 h; Inert atmosphere; 2: 2-chloro-5-carboxybenzene With tributylphosphine; cobalt(II) chloride in tetrahydrofuran T=20°C; Inert atmosphere; chemoselective reaction;
参考文献
Zeng, Jing; Liu, Kun Ming; Duan, Xin Fang
Organic Letters, 2013 , vol. 15, # 20 p. 5342 - 5345
