1-(4-乙氧基苯基)环丁烷-1-羧酸合成路线 （共 3 条）
反应条件
sodium hydroxide; ammonium chloride; sodium amide in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; diethyl ether; ethanol; ammonia
参考文献
Commonwealth Scientific and Industrial Research Organization
Patent: US4348409 A1, 1982 ;
反应条件
potassium hydroxide in diethylene glycol
8 h; Heating;
参考文献
Mndzhoyan, Sh. L.; Tsinker, M. G.; Ovakimyan, A. R.; Ter-Zakharyan, Yu. Z.; Kazaryan, E. V.; Paronikyan, R. V.
Pharmaceutical Chemistry Journal, 1980 , vol. 14, # 2 p. 114 - 118
Khimiko-Farmatsevticheskii Zhurnal, 1980 , vol. 14, # 2 p. 40 - 45
反应条件
1: 1.) sodium amide / 1.) toluene, heating, 1 h, 2.) overnight; heating, 6 h
2: 71.8 percent / KOH / bis-(2-hydroxy-ethyl) ether / 8 h / Heating
View Scheme
参考文献
Mndzhoyan, Sh. L.; Tsinker, M. G.; Ovakimyan, A. R.; Ter-Zakharyan, Yu. Z.; Kazaryan, E. V.; Paronikyan, R. V.
Pharmaceutical Chemistry Journal, 1980 , vol. 14, # 2 p. 114 - 118
Khimiko-Farmatsevticheskii Zhurnal, 1980 , vol. 14, # 2 p. 40 - 45
