5-氯-1,3-苯并二噁唑合成路线 （共 30 条）
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; [NiCl2(1,2-dimethoxyethane)]; caesium carbonate; zinc; tri-cyclo-hexyl-phosphine in ethylene glycol dimethyl ether; N,N-dimethyl-formamide
T=20 - 60°C; Suzuki-Miyaura cross-coupling reaction; 30 h; Inert atmosphere; chemoselective reaction;
参考文献
Tang, Shi; Takeda, Masahide; Nakao, Yoshiaki; Hiyama, Tamejiro
Chemical Communications, 2011 , vol. 47, # 1 p. 307 - 309
反应条件
tBu2P-N=P(iBuPCH2CH2)3N; tetrabutyl ammonium fluoride; palladium diacetate
T=80°C; Hiyama coupling; 2 h; Inert atmosphereNeat (no solvent);
参考文献
Raders, Steven M.; Kingston, Jesudoss V.; Verkade, John G.
Journal of Organic Chemistry, 2010 , vol. 75, # 5 p. 1744 - 1747
反应条件
tris-(dibenzylideneacetone)dipalladium(0); di-tert-butyl(2′,4′,6′-triisopropylbiphenyl-2-yl)phosphine in N,N-dimethyl-formamide
T=100°C; Inert atmosphere;
参考文献
Tolnai, Gergely L.; Petho, Balint; Krall, Peter; Novaka, Zoltan
Advanced Synthesis and Catalysis, 2014 , vol. 356, # 1 p. 125 - 129
反应条件
potassium phosphate; (1,2,3,4,5-pentaphenylferrocen-1'-yl)-di-tert-butylphosphine; bis(dibenzylideneacetone)-palladium(0) in toluene
T=100°C;
参考文献
Beare, Neil A.; Hartwig, John F.
Journal of Organic Chemistry, 2002 , vol. 67, # 2 p. 541 - 555
反应条件
1: triallyl(4-methoxyphenyl)silane With tetrabutyl ammonium fluoride in tetrahydrofuran; water
T=20°C; 1 h;
2: 1-chloro-3,4-methylenedioxybenzene With 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl; bis(η3-allyl-μ-chloropalladium(II)) in tetrahydrofuran; water
T=80°C; 4 h;
参考文献
Sahoo, Akhila K.; Oda, Takuro; Nakao, Yoshiaki; Hiyama, Tamejiro
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 13-15 p. 1715 - 1727
反应条件
caesium carbonate
T=20°C; 14 h; Inert atmosphereUV-irradiation;
参考文献
Lazzaroni, Simone; Protti, Stefano; Fagnoni, Maurizio; Albini, Angelo
Organic Letters, 2009 , vol. 11, # 2 p. 349 - 352
反应条件
styrene; [2,2']bipyridinyl; sodium hydride; bis(acetylacetonate)nickel(II); tris(2,4-pentanedionato-O,O')aluminum in tetrahydrofuran
Ullmann coupling; 3 h; Heating;
参考文献
Massicot, Fabien; Schneider, Raphael; Fort, Yves; Illy-Cherrey, Sandra; Tillement, Olivier
Tetrahedron, 2001 , vol. 57, # 3 p. 531 - 536
反应条件
4-MeO-dppp; palladium diacetate; ethylene glycol; potassium hydroxide
T=145°C; Heck reaction; 10 h; Inert atmosphere; regioselective reaction;
参考文献
Ruan, Jiwu; Iggo, Jonathan A.; Berry, Neil G.; Xiao, Jianliang
Journal of the American Chemical Society, 2010 , vol. 132, # 46 p. 16689 - 16699
反应条件
[Pd(η3-1-Ph-allyl)(μ-Cl)]2; sodium t-butanolate in 1,4-dioxane
T=90°C; 18 h; Inert atmosphereSealed tube;
参考文献
Crawford, Sarah M.; Alsabeh, Pamela G.; Stradiotto, Mark
European Journal of Organic Chemistry, 2012 , # 30 p. 6042 - 6050,9
反应条件
1: 1-chloro-3,4-methylenedioxybenzene With ethidium Bromide; magnesium; iron(II) chloride; magnesium chloride in tetrahydrofuran
T=22 - 52°C; 23 h;
2: chloro-trimethyl-silane in tetrahydrofuran
参考文献
Bogdanovi, Borislav; Schwickardi, Manfred
Angewandte Chemie - International Edition, 2000 , vol. 39, # 24 p. 4610 - 4612
