反应条件
1: 2-bromo-1,3-thiazole With n-butyllithium in diethyl ether; hexane
T=-78°C; Inert atmosphere;
2: benzonitrile in diethyl ether; hexane
T=-78 - 20°C; Inert atmosphere;
3: With hydrogenchloride; water in diethyl ether; hexane
T=0°C; 0.333333 h; Inert atmosphere;
参考文献
Ghorai, Prasanta; Kraus, Anja; Keller, Max; Goette, Carsten; Igel, Patrick; Schneider, Erich; Schnell, David; Bernhardt, Guenther; Dove, Stefan; Zabel, Manfred; Elz, Sigurd; Seifert, Roland; Buschauer, Armin
Journal of Medicinal Chemistry, 2008 , vol. 51, # 22 p. 7193 - 7204