4-氟-4-甲基-1,1-联苯合成路线 （共 47 条）
反应条件
1.1: 5.4 g / diethyl ether / 12 h / Heating
2.1: tetrabutylammonium fluoride trihydrate / tetrahydrofuran; H2O / 1 h / 20 °C
2.2: 99 percent / 2-dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl / [(η3-C3H5)PdCl]2 / tetrahydrofuran; H2O / 11 h / 80 °C
View Scheme
参考文献
Sahoo, Akhila K.; Oda, Takuro; Nakao, Yoshiaki; Hiyama, Tamejiro
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 13-15 p. 1715 - 1727
反应条件
1.1: silicon tetrachloride / diethyl ether / -20 - 20 °C
2.1: 5.4 g / diethyl ether / 12 h / Heating
3.1: tetrabutylammonium fluoride trihydrate / tetrahydrofuran; H2O / 1 h / 20 °C
3.2: 99 percent / 2-dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl / [(η3-C3H5)PdCl]2 / tetrahydrofuran; H2O / 11 h / 80 °C
View Scheme
参考文献
Sahoo, Akhila K.; Oda, Takuro; Nakao, Yoshiaki; Hiyama, Tamejiro
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 13-15 p. 1715 - 1727
反应条件
morpholine; K3PO4*3H2O; NHC-Pd(II)-Im
T=120°C; Suzuki-Miyaura coupling; 24 h; Inert atmosphere;
参考文献
Wang, Zhan-Yong; Chen, Gao-Qi; Shao, Li-Xiong
Journal of Organic Chemistry, 2012 , vol. 77, # 15 p. 6608 - 6614
反应条件
1-phenyl-3-isopropylimidazolium iodide; palladium diacetate; caesium carbonate in 1,4-dioxane
T=80°C; Suzuki-Miyaura coupling; 24 h; Inert atmosphere;
参考文献
Xu, Xiangya; Xu, Baochang; Li, Yongxin; Hong, Soon Hyeok
Organometallics, 2010 , vol. 29, # 23 p. 6343 - 6349
反应条件
tetrakis(triphenylphosphine) palladium(0) in various solvent(s)
T=80°C; 5 h; Title compound not separated from byproducts;
参考文献
Catellani, Marta; Chiusoli, Gian Paolo; Fornasari, Vilma
Gazzetta Chimica Italiana, 1990 , vol. 120, p. 779 - 781
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
T=25°C; Negishi cross-coupling; 96 h; Inert atmosphere;
参考文献
Dong, Zhi-Bing; Manolikakes, Georg; Shi, Lei; Knochel, Paul; Mayr, Herbert
Chemistry - A European Journal, 2010 , vol. 16, # 1 p. 248 - 253
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
T=25°C; Negishi cross-coupling; 48 h; Inert atmosphere;
参考文献
Dong, Zhi-Bing; Manolikakes, Georg; Shi, Lei; Knochel, Paul; Mayr, Herbert
Chemistry - A European Journal, 2010 , vol. 16, # 1 p. 248 - 253
反应条件
palladium diacetate; potassium carbonate; 2,2,2-trimethylacetic acid in N,N-dimethyl acetamide
T=110°C; Inert atmosphere;
参考文献
Tan, Yichen; Hartwig, John F.
Journal of the American Chemical Society, 2011 , vol. 133, # 10 p. 3308 - 3311
反应条件
1: potassium hydroxide / tetrahydrofuran / 20 °C
2: 1,1'-bis(diphenylphosphanyl)ferrocenenickel(II) chloride; potassium phosphate / toluene / 24 h / 110 °C / |Schlenk technique
View Scheme
参考文献
Li, Xiao-Jian; Zhang, Jin-Ling; Geng, Yu; Jin, Zhong
Journal of Organic Chemistry, 2013 , vol. 78, # 10 p. 5078 - 5084
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / |Schlenk technique; |Inert atmosphere
1.2: -90 - 20 °C / |Schlenk technique; |Inert atmosphere
2.1: bis-triphenylphosphine-palladium(II) chloride; potassium hydroxide / neat (no solvent) / 24 h / 110 °C / |Schlenk technique; |Inert atmosphere
View Scheme
参考文献
Asachenko, Andrey F.; Sorochkina, Kristina R.; Dzhevakov, Pavel B.; Topchiy, Maxim A.; Nechaev, Mikhail S.
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 18 p. 3553 - 3557
