1,4-双(3-氨基丙基)哌嗪合成路线 （共 13 条）
反应条件
hydrogenchloride in methanol T=20°C; 1 h;
参考文献
ARGENTA DISCOVERY LTD
Patent: WO2006/82412 A2, 2006 ;
Location in patent: Page/Page column 78 ;
WO 2006/082412 A2
反应条件
in methanol T=65 - 70°C; 2 h;
参考文献
Sogang University Research Foundation; HUR, Nam Hwi; LEE, Byeong No
Patent: US2014/51858 A1, 2014 ;
Location in patent: Paragraph 0081-0082 ;
反应条件
methanol; ammonia; nickel T=90°C; P=102971 - 128714 Torr; Hydrogenation;
参考文献
Journal of the American Chemical Society, , vol. 68, p. 1296
反应条件
methanol; ammonia; nickel T=90°C; P=102971 - 128714 Torr; Hydrogenation;
参考文献
Journal of the American Chemical Society, , vol. 68, p. 1296
反应条件
1: With dimethylsulfide borane complex in tetrahydrofuran 48 h; Heating; 2: in hydrogenchloride Heating; 3: With sodium hydroxide Heating;
参考文献
Bernard, Helene; Del Rio Garcia, Eugenia; Ferec, Sonia; Kervarec, Nelly; Handel, Henri
European Journal of Organic Chemistry, 2003 , # 2 p. 255 - 258
反应条件
sodium tetrahydroborate in ethanol T=-10°C; 2 h;
参考文献
European Journal of Organic Chemistry, , # 6 p. 1050 - 1055
反应条件
in tetrahydrofuran T=20°C;
参考文献
Paisner, Kathryn; Zakharov, Lev N.; Doxsee, Kenneth M.
Crystal Growth and Design, 2010 , vol. 10, # 8 p. 3757 - 3762
参考文献
Carpino, Louis A.; Sadat-Aalaee, Dean; Beyermann, Michael
Journal of Organic Chemistry, 1990 , vol. 55, # 5 p. 1673 - 1675
参考文献
Ducrocq, Claire; Wendling, Francoise; Tourbez-Perrin, Martine; Rivalle, Christian; Tambourin, Pierre; et al.
Journal of Medicinal Chemistry, 1980 , vol. 23, # 11 p. 1212 - 1216
反应条件
in ethanol
3 h; Reflux;
参考文献
Keypour, Hassan; Rezaeivala, Majid; Dehghani-Firouzabadi, Ahmad A.M.
Journal of Chemical Research, 2009 , # 2 p. 126 - 128
