4-氨基-5-氯-2-甲氧基苯甲酸合成路线 （共 38 条）
反应条件
hydrogenchloride in ethanol; water
参考文献
Anphar, S.A.
Patent: US4138492 A1, 1979 ;
反应条件
1: With potassium hydroxide in ethanol; water Heating / reflux; 2: With hydrogenchloride in ethanol; water
参考文献
WO2005/23808 A2, ;
Page/Page column 37-38 ;
反应条件
potassium hydroxide Hydrolysis;
参考文献
Ehrenkaufer, Richard L.; Scripko, James G.; Hoffman, Patricia L.
Organic Preparations and Procedures International, 1992 , vol. 24, # 1 p. 64 - 66
反应条件
1: 74 percent / N-chlorosuccinimide / acetonitrile / 1 h / Heating 2: 86 percent / aq. KOH View Scheme
参考文献
Organic Preparations and Procedures International, , vol. 24, # 1 p. 64 - 66
反应条件
1: N-chloro-succinimide / N,N-dimethyl-formamide 2: sodium hydroxide / ethanol View Scheme
参考文献
Letters in Drug Design and Discovery, , vol. 9, # 5 p. 489 - 493
反应条件
1: sodium hydroxide / N,N-dimethyl-formamide 2: N-chloro-succinimide / N,N-dimethyl-formamide 3: sodium hydroxide / ethanol View Scheme
参考文献
Letters in Drug Design and Discovery, , vol. 9, # 5 p. 489 - 493
反应条件
1: sulfuric acid / 2 h / 20 °C 2: acetic acid / 1 h 3: sodium hydroxide / N,N-dimethyl-formamide 4: N-chloro-succinimide / N,N-dimethyl-formamide 5: sodium hydroxide / ethanol View Scheme
参考文献
Letters in Drug Design and Discovery, , vol. 9, # 5 p. 489 - 493
反应条件
1: acetic acid / 1 h 2: sodium hydroxide / N,N-dimethyl-formamide 3: N-chloro-succinimide / N,N-dimethyl-formamide 4: sodium hydroxide / ethanol View Scheme
参考文献
Letters in Drug Design and Discovery, , vol. 9, # 5 p. 489 - 493
反应条件
sodium hydroxide; triethylamine in chloroform; water
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US4242507 A1, 1980 ;
反应条件
1: triethylamine / tetrahydrofuran / 1 h / 0 °C 2: tetrahydrofuran / 3 h / Ambient temperature View Scheme
参考文献
Harrold, Marc W.; Sriburi, Anong; Matsumoto, Kazuhisa; Miller, Duane D.; Farooqui, Tahira; Uretsky, Norman
Journal of Medicinal Chemistry, 1993 , vol. 36, # 21 p. 3166 - 3170
