triethylamine in water; acetonitrile 1 h;

N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=20°C; 2 h;

1: diisopropylethylamine / ethyl acetate 2: 240 h 3: zinc, acetic acid View Scheme

sodium carbonate 1.) H2O, r.t., 24 h; 2.) p-dioxane, 0 deg C to r.t., 24 h; other reagent (1. step): NaOH; Yield given. Multistep reaction;

1: 240 h 2: zinc, acetic acid View Scheme

暂无反应条件数据

1: With 4-methyl-morpholine in ethylene glycol dimethyl ether T=-15°C; 1 h; 2: With sodium tetrahydroborate in ethylene glycol dimethyl ether; water T=-15°C; Further stages.;

1: 1.) i-BuOCOCl, NMM / 1.) THF, -20 deg C, 20 min, 2.) THF, Et2O, -5 deg C, 4 h 2: 70 percent / CF3COOAg, NMM / tetrahydrofuran; H2O / 8 h View Scheme

1: N-α-Fmoc-L-glutamic acid γ-t-butyl ester With methanol; N-ethyl-N,N-diisopropylamine in chloroform T=20°C; 2 h; 2: With 4-methyltetrahydropyridine in chloroform; N,N-dimethyl-formamide 3: BOC-glycine; N-(9H-fluoren-9-ylmethyloxycarbonylamino)-L-alanine; fmoc-L-Ser(TBu)-OH; N-(9-fluorenylmethoxycarbonyl)-L-aspartic acid-β-(tert-butyl)ester; N-(tert-butoxycarbonyl)-L-tryptophan Further stages;

triethylsilane; trifluoroacetic acid in dichloromethane 0.25 h; Ambient temperature;