反应条件
1.1: AlCl3, aluminium chloride; lithium aluminium tetrahydride / diethyl ether / 0 °C / |Reflux
2.1: silver nitrate; acetyl chloride / acetonitrile; water / 5 h / 0 - 20 °C
3.1: palladium 10 on activated carbon; hydrogen / methanol; tetrahydrofuran / 2 h / 20 °C
4.1: pyridine / 1,4-dioxane / 16 h / 0 - 20 °C
5.1: nitric acid; acetic acid / 15 °C
5.2: 0.5 h / |Cooling with ice
6.1: hydrogenchloride / ethanol / 2 h / |Reflux
7.1: isopentyl nitrite / tetrahydrofuran / 3.25 h / 0 °C / |Reflux
View Scheme
参考文献
Lee, Jeewoo; Tran, Phuong-Thao; Hoang, Van-Hai; Thorat, Shivaji A.; Kim, Sung Eun; Ann, Jihyae; Chang, Yu Jin; Nam, Dong Woo; Song, Hyundong; Mook-Jung, Inhee; Lee, Jiyoun
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 13 p. 3821 - 3830