2-氨基-3-氰基-4-甲基吡啶合成路线 （共 9 条）
反应条件
ammonia in ethanol 2.25 h; Heating / reflux;
参考文献
BOEHRINGER INGELHEIM PHARMACEUTICALS INC.
Patent: EP1064265 B1, 2004 ;
Location in patent: Page 4 ;
反应条件
hydrogenchloride in methanolic ammonia; ethyl acetate
反应条件
ammonia in methanol T=20°C;
参考文献
Chan, David C. M.; Rosowsky, Andre
Journal of Organic Chemistry, 2005 , vol. 70, # 4 p. 1364 - 1368
参考文献
Troschutz; Dennstedt
Archiv der Pharmazie, 1994 , vol. 327, # 2 p. 85 - 89
反应条件
ammonia T=150°C; 3 h;
参考文献
Smetskaya, N. I.; Mukhina, N. A.; Granik, V. G.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1984 , vol. 20, # 6 p. 650 - 653
Khimiya Geterotsiklicheskikh Soedinenii, 1984 , vol. 20, # 6 p. 799 - 802
反应条件
in N,N-dimethyl-formamide 20 h; Heating;
参考文献
Dunn; Norrie
Advanced Synthesis and Catalysis, 1996 , vol. 338, # 7 p. 663 - 666
反应条件
N-iodo-succinimide in N,N-dimethyl-formamide T=0 - 20°C;
参考文献
Chan, David C. M.; Rosowsky, Andre
Journal of Organic Chemistry, 2005 , vol. 70, # 4 p. 1364 - 1368
反应条件
N-bromosuccinmide in N,N-dimethyl-formamide T=0 - 20°C;
参考文献
Chan, David C. M.; Rosowsky, Andre
Journal of Organic Chemistry, 2005 , vol. 70, # 4 p. 1364 - 1368
反应条件
1: 92 percent / N-bromosuccinimide / dimethylformamide / 0 - 20 °C
2: 59 percent / PdCl2(dppf)*CH2Cl2 / tetrahydrofuran / 4 h / Heating
3: 43 percent / SbBr3; t-BuONO / various solvent(s) / 6 h / 4 - 10 °C
4: 38 percent / sodium methoxide; pyridine / 3 h / Heating
View Scheme
参考文献
Chan, David C. M.; Rosowsky, Andre
Journal of Organic Chemistry, 2005 , vol. 70, # 4 p. 1364 - 1368
