1-甲基环丙烷-1-甲酸乙酯合成路线 （共 9 条）
参考文献
Journal of the American Chemical Society, , vol. 81, p. 1660,1665
反应条件
1: 65 percent / n-Bu4NBr / CuCl / Irradiation 2: 73 percent / Et4NO3SC6H4Me-p / dimethylsulfoxide / electrolysis View Scheme
参考文献
Journal of the Chemical Society, Chemical Communications, , # 23 p. 1446 - 1447
反应条件
1: cyclopropanecarboxylic acid ethyl ester With n-butyllithium; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide in tetrahydrofuran; hexane T=-78°C; 1 h; Inert atmosphere; 2: methyl iodide in tetrahydrofuran; hexane T=20°C; 10 h; Inert atmosphere;
参考文献
Journal of the American Chemical Society, , vol. 135, # 16 p. 6030 - 6032
反应条件
hydrogen; palladium on activated charcoal in ethanol T=20°C; 0.416667 h; the formed products are detected with gas chromatography; Product distribution;
参考文献
Liebigs Annalen der Chemie, , # 7 p. 1485 - 1491
反应条件
hydrogen; palladium on activated charcoal in ethanol T=100°C; P=117681 Torr; 48 h; the formed products are detected with gas chromatography; Product distribution;
参考文献
Hertzsch, Winfried; Musso, Hans
Liebigs Annalen der Chemie, 1985 , # 7 p. 1485 - 1491
反应条件
hydrogen; palladium on activated charcoal in ethanol T=100°C; P=117681 Torr; 48 h; the formed products are detected with gas chromatography; Product distribution;
参考文献
Liebigs Annalen der Chemie, , # 7 p. 1485 - 1491
反应条件
1: With methanol; sodium hydroxide; water T=50 - 60°C; 5 h; 2: With hydrogenchloride; water pH=1;
参考文献
ELI LILLY AND COMPANY
Patent: WO2007/53346 A1, 2007 ;
Location in patent: Page/Page column 21 ;
WO 2007/053346 A1
反应条件
1.1: sodium hydroxide / methanol / 60 °C 1.2: pH 2 2.1: thionyl chloride / 3 h / 85 °C / |Inert atmosphere View Scheme
参考文献
Shang, Rui; Ilies, Laurean; Matsumoto, Arimasa; Nakamura, Eiichi
Journal of the American Chemical Society, 2013 , vol. 135, # 16 p. 6030 - 6032
反应条件
hydrazine hydrate in toluene
参考文献
Dainippon Pharmaceutical Co., Ltd.
Patent: US5367078 A1, 1994 ;
