6-氯-2-甲基-4-羟基喹唑啉合成路线 （共 8 条）
反应条件
copper(l) iodide; caesium carbonate in N,N-dimethyl-formamide T=25°C; 12 h; Inert atmosphere;
参考文献
Liu, Xiaowei; Fu, Hua; Jiang, Yuyang; Zhao, Yufen
Angewandte Chemie - International Edition, 2009 , vol. 48, # 2 p. 348 - 351
反应条件
1: With caesium carbonate; L-proline in N,N-dimethyl-formamide T=20°C; 0.5 h; Inert atmosphere; 2: With copper(l) iodide in N,N-dimethyl-formamide T=20 - 80°C; 20 h; Inert atmosphere;
参考文献
Huang, Cheng; Fu, Yuan; Fu, Hua; Jiang, Yuyang; Zhao, Yufen
Chemical Communications, 2008 , # 47 p. 6333 - 6335
反应条件
ammonium hydroxide in ethanol T=20°C; Substitution; 48 h;
参考文献
Santagati, Natale Alfredo; Bousquet, Ennio; Spadaro, Angelo; Ronsisvalle, Giuseppe
Farmaco, 1999 , vol. 54, # 11-12 p. 780 - 784
反应条件
1: T=120°C; 3 h; 2: With ammonia in water 4 h; Reflux;
参考文献
Okano, Masahiko; Mito, Jun; Maruyama, Yasufumi; Masuda, Hirofumi; Niwa, Tomoko; Nakagawa, Shin-ichiro; Nakamura, Yoshitaka; Matsuura, Akira
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 1 p. 119 - 132
反应条件
1: in N,N-dimethyl-formamide T=20°C; 0.166667 h; Inert atmosphere; 2: With iron (III) acetylacetonate; caesium carbonate; N-methyl-2-(methylamino)ethylamine in N,N-dimethyl-formamide Microwave irradiationInert atmosphere;
参考文献
Zhang, Xiaodong; Ye, Deju; Sun, Haifeng; Guo, Diliang; Wang, Jiang; Huang, He; Zhang, Xu; Jiang, Hualiang; Liu, Hong
Green Chemistry, 2009 , vol. 11, # 11 p. 1881 - 1888
参考文献
Journal of the American Chemical Society, , vol. 70, p. 2423
反应条件
1: 92 percent / acetic anhydride / 3 h / Heating 2: 90 percent / aq. NH3 / ethanol / 48 h / 20 °C View Scheme
参考文献
Farmaco, , vol. 54, # 11-12 p. 780 - 784
反应条件
1: 75.8 percent / 2 h / Heating 2: 54.4 percent / ammonium acetate / 0.5 h / 150 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 6 p. 1721 - 1728
