N-(2-羟基乙基)辛酰胺合成路线 （共 9 条）
反应条件
1: With sodium hydroxide; sodium hypochlorite; 4-acetylamino 2,2,6,6-tetramethylpiperidin-N-oxyl; potassium bromide in water; toluene T=31 - 38°C; pH=6.9 - 8.9; 5 - 6 h; 2: With hydrogenchloride in tetrahydrofuran; water; toluene pH=2.2; Product distribution / selectivity;
参考文献
Conopco, Inc., d/b/a UNILEVER
Patent: US2007/299269 A1, 2007 ;
Location in patent: Page/Page column 6; 7 ;
反应条件
1: With sodium hydroxide; sodium hypochlorite; 4-acetylamino 2,2,6,6-tetramethylpiperidin-N-oxyl; potassium bromide in water; toluene T=31 - 38°C; pH=6.9 - 8.9; 5 - 6 h; 2: With hydrogenchloride in tetrahydrofuran; water; toluene pH=2.2; Product distribution / selectivity;
参考文献
Conopco, Inc., d/b/a UNILEVER
Patent: US2007/299269 A1, 2007 ;
Location in patent: Page/Page column 6; 7 ;
反应条件
2,6-di-tert-butyl-4-methyl-phenol
T=140 - 165°C; 5 h; Inert atmosphere;
参考文献
GALAXY SURFACTANTS LTD.; KOSHTI, Nirmal; RATNAPARKHE, Shraddha, Kiran; MALI, Devyani, Ashok; SAWANT, Bhagyesh; VAIDYA, Pooja, Dinkar
Patent: WO2013/76697 A2, 2013 ;
Location in patent: Page/Page column 18-19 ;
反应条件
triethylamine in dichloromethane
T=20°C; 15 h;
参考文献
Block, Marco A. Balbo; Hecht, Stefan
Macromolecules, 2004 , vol. 37, # 13 p. 4761 - 4769
反应条件
1: oxalyl chloride; DMF / CH2Cl2 / 3 h / Heating
2: 81 percent / triethylamine / CH2Cl2 / 15 h / 20 °C
View Scheme
参考文献
Block, Marco A. Balbo; Hecht, Stefan
Macromolecules, 2004 , vol. 37, # 13 p. 4761 - 4769
反应条件
in dichloromethane
T=20°C; Cooling with ice;
参考文献
Guan, Li-Ping; Zhao, Dong-Hai; Xiu, Jing-Hui; Sui, Xin; Piao, Hu-Ri; Quan, Zhe-Shan
Archiv der Pharmazie, 2009 , vol. 342, # 1 p. 34 - 40
反应条件
1: With sodium hydroxide; sodium hypochlorite; 4-acetylamino 2,2,6,6-tetramethylpiperidin-N-oxyl; potassium bromide in water; toluene
T=31 - 38°C; pH=6.9 - 8.9; 5 - 6 h;
2: With hydrogenchloride in tetrahydrofuran; water; toluene
pH=2.2; Product distribution / selectivity;
参考文献
Conopco, Inc., d/b/a UNILEVER
Patent: US2007/299269 A1, 2007 ;
Location in patent: Page/Page column 6; 7 ;
反应条件
1: With sodium hydroxide; sodium hypochlorite; 4-acetylamino 2,2,6,6-tetramethylpiperidin-N-oxyl; potassium bromide in water; toluene
T=31 - 38°C; pH=6.9 - 8.9; 5 - 6 h;
2: With hydrogenchloride in tetrahydrofuran; water; toluene
pH=2.2; Product distribution / selectivity;
参考文献
Conopco, Inc., d/b/a UNILEVER
Patent: US2007/299269 A1, 2007 ;
Location in patent: Page/Page column 6; 7 ;
反应条件
1: With sodium hydroxide; sodium hypochlorite; 4-acetylamino 2,2,6,6-tetramethylpiperidin-N-oxyl; potassium bromide in water; toluene
T=31 - 38°C; pH=6.9 - 8.9; 5 - 6 h;
2: With hydrogenchloride in tetrahydrofuran; water; toluene
pH=2.2; Product distribution / selectivity;
参考文献
Conopco, Inc., d/b/a UNILEVER
Patent: US2007/299269 A1, 2007 ;
Location in patent: Page/Page column 6; 7 ;
