5-甲酰基吡嗪-2-羧酸甲酯合成路线 （共 3 条）
反应条件
sodium periodate in tetrahydrofuran; water
T=25°C; 0.5 h;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2004/52869 A1, 2004 ;
Location in patent: Page 140 ;
WO 2004/052869 A1
反应条件
silver nitrate in tetrahydrofuran; water
T=80°C; 1.25 h;
参考文献
Carruthers, Nicholas I.; Shah, Chandravadan R.; Swanson, Devin M.
Patent: US2005/222151 A1, 2005 ;
Location in patent: Page/Page column 19-20 ;
US 20050222151 A1
反应条件
iodine; dimethyl sulfoxide; trifluoroacetic acid
T=160°C; Kornblum oxidation; 3 h; Inert atmosphere;
参考文献
Swanson, Devin M.; Shah, Chandra R.; Lord, Brian; Morton, Kirsten; Dvorak, Lisa K.; Mazur, Curt; Apodaca, Richard; Xiao, Wei; Boggs, Jamin D.; Feinstein, Mark; Wilson, Sandy J.; Barbier, Ann J.; Bonaventure, Pascal; Lovenberg, Timothy W.; Carruthers, Nicholas I.
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 11 p. 4413 - 4425
