4-氯-2,6-吡啶二羰基二氯合成路线 （共 33 条）
反应条件
pyridine in dichloromethane T=0 - 20°C; 5 h;
参考文献
Cell Therapeutics, Inc.
Patent: US2004/198728 A1, 2004 ;
Location in patent: Page/Page column 8 ;
参考文献
Tse, Man Kin; Bhor, Santosh; Klawonn, Markus; Anilkumar, Gopinathan; Jiao, Haijun; Doebler, Christian; Spannenberg, Anke; Magerlein, Wolfgang; Hugl, Herbert; Beller, Matthias
Chemistry - A European Journal, 2006 , vol. 12, # 7 p. 1855 - 1874
参考文献
Bridger, Gary J.; Skerlj, Renato T.; Padmanabhan, Sreenivasan; Martellucci, Stephen A.; Henson, Geoffrey W.; Struyf, Sofie; Witvrouw, Myriam; Schols, Dominique; De Clercq, Erik
Journal of Medicinal Chemistry, 1999 , vol. 42, # 19 p. 3971 - 3981
反应条件
2: 64 percent / NaBH4 / ethanol / 16 h / Heating View Scheme
参考文献
Bridger, Gary J.; Skerlj, Renato T.; Padmanabhan, Sreenivasan; Martellucci, Stephen A.; Henson, Geoffrey W.; Struyf, Sofie; Witvrouw, Myriam; Schols, Dominique; De Clercq, Erik
Journal of Medicinal Chemistry, 1999 , vol. 42, # 19 p. 3971 - 3981
反应条件
1: 1 h 2: 98 percent / aq. NaOH / 1 h / Heating 3: 61 percent / conc. H2SO4 / H2O / 12 h / 20 °C View Scheme
参考文献
Iglesias, Carlos Platas; Elhabiri, Mourad; Hollenstein, Marcel; Buenzli, Jean-Claude G.; Piguet, Claude
Journal of the Chemical Society, Dalton Transactions, 2000 , # 13 p. 2031 - 2043
反应条件
1: dichloromethane / 2 h / 0 - 20 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 0.67 h / 0 °C View Scheme
参考文献
Ivchenko, Pavel V.; Nifant'Ev, Ilya E.; Buslov, Ivan V.
Tetrahedron Letters, 2013 , vol. 54, # 3 p. 217 - 219
反应条件
1: 68 percent / diethyl ether / 1 h / 0 °C 2: 99 percent / aq. HI / CH2Cl2 / 48 h View Scheme
参考文献
Ivchenko, Pavel V.; Nifant'Ev, Ilya E.; Buslov, Ivan V.
Tetrahedron Letters, 2013 , vol. 54, # 3 p. 217 - 219
反应条件
acetic acid Yield given. Multistep reaction;
参考文献
Fallahpour, Reza-Ali; Constable, Edwin C.
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 16 p. 2263 - 2264
反应条件
thionyl chloride; N,N-dimethyl-formamide
2 h; Reflux;
参考文献
De Bo, Guillaume; De Winter, Julien; Gerbaux, Pascal; Fustin, Charles-Andre
Angewandte Chemie - International Edition, 2011 , vol. 50, # 39 p. 9093 - 9096
反应条件
N-(chloromethylene)-N-methylmethanaminium chloride; triethylamine; N,N-dimethyl-formamide in acetonitrile
T=75°C; P=5171.62 Torr; 0.95 h;
参考文献
Battilocchio, Claudio; Baumann, Marcus; Baxendale, Ian R.; Biava, Mariangela; Kitching, Matthew O.; Ley, Steven V.; Martin, Rainer E.; Ohnmacht, Stephan A.; Tappin, Nicholas D. C.
Synthesis, 2012 , vol. 44, # 4 p. 635 - 647
