4-(三氟甲氧基)苯甲醚合成路线 （共 14 条）
反应条件
1: With trifluoromethanesulfonic acid trifluoromethyl ester; sodium hydrogencarbonate in tetrahydrofuran T=-30°C; Inert atmosphere; 2: With AgPF6; F-TEDA-PF6 in tetrahydrofuran; acetone T=-30 - 23°C; Inert atmosphereDarkness;
参考文献
Huang, Chenghong; Liang, Theresa; Harada, Shinji; Lee, Eunsung; Ritter, Tobias
Journal of the American Chemical Society, 2011 , vol. 133, # 34 p. 13308 - 13310
反应条件
in 1,2-dichlorotrifluoroethyl-trifluoromethylether T=-40°C; Inert atmosphere;
参考文献
Journal of Fluorine Chemistry, , vol. 140, p. 43 - 48
反应条件
1: (4-methoxyphenyl)-boronic acid With sodium hydroxide in methanol T=23°C; 0.25 h; Inert atmosphere; 2: With AgPF6 in methanol T=0°C; 0.5 h; Inert atmosphere; 3: tris(dimethylamino)sulfonium trifluoromethoxide Further stages;
参考文献
Huang, Chenghong; Liang, Theresa; Harada, Shinji; Lee, Eunsung; Ritter, Tobias
Journal of the American Chemical Society, 2011 , vol. 133, # 34 p. 13308 - 13310
反应条件
1: 5-tert-butyl-2'-(trifluoromethoxy)biphenylyl-2-diazonium hexafluoroantimonate in dichloromethane T=-100 - -90°C; 1.16667 h; Irradiation; 2: 4-methoxy-phenol With N-ethyl-N,N-diisopropylamine in dichloromethane T=-90 - -10°C; 3 h; Further stages.;
参考文献
Journal of Organic Chemistry, , vol. 72, # 18 p. 6905 - 6917
参考文献
Belter, Randolph K.
Journal of Fluorine Chemistry, 2010 , vol. 131, # 12 p. 1302 - 1307
反应条件
sodium in tetrahydrofuran T=80°C; 24 h; chemoselective reaction;
参考文献
Iijima, Akinori; Amii, Hideki
Tetrahedron Letters, 2008 , vol. 49, # 41 p. 6013 - 6015
反应条件
hydrogen fluoride; tantalum pentachloride
参考文献
Journal of Fluorine Chemistry, , vol. 131, # 12 p. 1302 - 1307
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane T=-30°C; 0.666667 h; 2: With triisopropyl borane in tetrahydrofuran; hexane T=-78°C; 1.08333 h; 3: With hydrogenchloride; water in tetrahydrofuran; hexane T=-78 - 20°C; 0.5 h;
参考文献
PFIZER LIMITED
Patent: WO2006/67587 A2, 2006 ;
Location in patent: Page/Page column 27 ;
反应条件
sodium hydroxide; 1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane; trifluoroacetic acid in dichloromethane; water
参考文献
Pfizer Inc.
Patent: US5294744 A1, 1994 ;
反应条件
1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane in 1,4-dioxane; water T=80°C;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/821 A1, 2005 ;
Location in patent: Page 49 ;
WO 2005/000821 A1
