反应条件
1: AcOK; dichloro[1,1'-bis(diphenylphosphino)ferrocene]Pd(II)*CH2Cl2; DMSO / dioxane / 14 h / 90 °C
2: KF; tris(dibenzylideneacetone)dipalladium; tri-tert-butylphosphine / tetrahydrofuran; dioxane / 1.5 h / 20 - 50 °C
3: SnCl2*2H2O / ethanol; tetrahydrofuran / 12 h / 20 °C
4: aq. HBr; NaNO2; CuBr / dioxane / 0.5 h / 5 - 50 °C
View Scheme
参考文献
Goodacre, Simon C.; Street, Leslie J.; Hallett, David J.; Crawforth, James M.; Kelly, Sarah; Owens, Andrew P.; Blackaby, Wesley P.; Lewis, Richard T.; Stanley, Joanna; Smith, Alison J.; Ferris, Pushpinder; Sohal, Bindi; Cook, Susan M.; Pike, Andrew; Brown, Nicola; Wafford, Keith A.; Marshall, George; Castro, Jose L.; Atack, John R.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 1 p. 35 - 38