D-苹果酸二甲酯合成路线

67-56-1甲醇+636-61-3D-(+)-苹果酸→70681-41-3D-苹果酸二甲酯

参考文献

Kodra, Janos T.; Jorgensen, Anker Steen; Andersen, Birgitte; Behrens, Carsten; Brand, Christian Lehn; Christensen, Inger Thoger; Guldbrandt, Mette; Jeppesen, Claus Bekker; Knudsen, Lotte B.; Madsen, Peter; Nishimura, Erica; Sams, Christian; Sidelmann, Ulla G.; Pedersen, Raymon A.; Lynn, Francis C.; Lau, Jesper
Journal of Medicinal Chemistry, 2008 , vol. 51, # 17 p. 5387 - 5396

636-61-3D-(+)-苹果酸+104-15-4对甲苯磺酸→70681-41-3D-苹果酸二甲酯

参考文献

VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2007/21982 A2, 2007 ;
Location in patent: Page/Page column 67 ;

67-56-1甲醇+106-48-9对氯苯酚→553-90-2草酸二甲酯+70681-41-3D-苹果酸二甲酯+624-48-6马来酸二甲酯+108-59-8丙二酸二甲酯

参考文献

Journal of Molecular Catalysis A: Chemical, , vol. 371, p. 15 - 20

72229-29-9→70681-41-3D-苹果酸二甲酯

参考文献

Hungerbuehler, Ernst von; Seebach, Dieter; Wasmuth, Daniel
Helvetica Chimica Acta, 1981 , vol. 64, # 5 p. 1467 - 1487

56958-97-5→70681-41-3D-苹果酸二甲酯

参考文献

Torii, Sigeru; Okumoto, Hiroshi; Nakayasu, Seizo; Kotani, Takayuki
Chemistry Letters, 1989 , p. 1975 - 1978

25007-54-92-氧代琥珀酸二甲酯→70681-41-3D-苹果酸二甲酯

参考文献

Kayser, Margaret M.; Mihovilovic, Marko D.; Kearns, Jeff; Feicht, Anton; Stewart, Jon D.
Journal of Organic Chemistry, 1999 , vol. 64, # 18 p. 6603 - 6608

474385-61-0→70681-41-3D-苹果酸二甲酯

参考文献

Evans, David A; Masse, Craig E; Wu, Jimmy
Organic letters, 2002 , vol. 4, # 20 p. 3375 - 3378

105281-79-6→70681-41-3D-苹果酸二甲酯

参考文献

Alpegiani, Marco; Hanessian, Stephen
Journal of Organic Chemistry, 1987 , vol. 52, # 2 p. 278 - 279

25007-54-92-氧代琥珀酸二甲酯→617-55-0L-苹果酸二甲酯+70681-41-3D-苹果酸二甲酯

参考文献

Canadian Journal of Chemistry, , vol. 76, # 10 p. 1447 - 1456

636-61-3D-(+)-苹果酸+75-36-5乙酰氯→70681-41-3D-苹果酸二甲酯

参考文献

US2002/143186 A1, ;