5-(4-甲基苯基)异噁唑合成路线 （共 8 条）
反应条件
hydrogenchloride in dichloromethane; water
T=20°C; 1 h;
参考文献
Kivrak, Arif; Zora, Metin
Tetrahedron, 2014 , vol. 70, # 4 p. 817 - 831
反应条件
sodium hydrogencarbonate; hydroxylamine-o-sulphonic acid in methanol; water
参考文献
Novartis AG
Patent: US5977075 A1, 1999 ;
US 5977075 A
反应条件
H2OH*HCl in tetrahydrofuran; water
T=20°C; 17 h;
参考文献
Swain, Christopher J.; Teran, Ana; Maroto, Marta; Cabello, Angeles
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 23 p. 6058 - 6062
反应条件
1: NaH / tetrahydrofuran / 2.5 h / 20 °C
2: H2OH*HCl / tetrahydrofuran; H2O / 17 h / 20 °C
View Scheme
参考文献
Swain, Christopher J.; Teran, Ana; Maroto, Marta; Cabello, Angeles
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 23 p. 6058 - 6062
反应条件
1: NH2OH*HCl, CH3ONa / methanol / 5 h / Heating
2: hydrochloric acid / methanol / 1 h / Heating
View Scheme
参考文献
Molina, P.; Fresneda, P. M.
Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 461 - 464
反应条件
hydroxylamine-o-sulphonic acid
1.) reflux, 2.) MeOH, RT; Yield given. Multistep reaction;
参考文献
Sakaki, Junichi; Murata, Toshiki; Yuumoto, Yoko; Nakamura, Ikushi; Frueh, Thomas; Pitterna, Thomas; Iwasaki, Genji; Oda, Kyoko; Yamamura, Takaki; Hayakawa, Kenji
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 16 p. 2241 - 2246
反应条件
hydrogenchloride; methanol; hydroxylamine
参考文献
Kotschetkow et al.
Zhurnal Obshchei Khimii, 1957 , vol. 27, p. 452,456; engl. Ausg. S. 511, 514
反应条件
acetyl chloride
1 h;
参考文献
Woodward,R.B. et al.
Tetrahedron, Supplement, 1966 , vol. 8, p. 321 - 340
