1.1: 89 percent / PBr3 / CH2Cl2 / 12 h / 0 °C 2.1: 92 percent / toluene / 12 h / Heating 3.1: n-BuLi / tetrahydrofuran / -78 °C 3.2: tetrahydrofuran 4.1: 88 percent / Bu4NF / tetrahydrofuran / 0.75 h View Scheme
参考文献
Pettit, George R.; Grealish, Matthew P.; Jung, M. Katherine; Hamel, Ernest; Pettit, Robin K.; Chapuis, J.-Charles; Schmidt, Jean M.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 12 p. 2534 - 2542
1: (4-methoxybenzyl)triphenylphosphonium chloride With n-butyllithium in tetrahydrofuran; hexane T=0°C; Wittig type reaction; 2: 3,5-dimethoxy-benzyl alcohol With 4,4'-di-tert-butylbiphenyl; lithium; nickel dichloride in tetrahydrofuran; hexane Wittig type reaction; 12 h; Inert atmosphereReflux; optical yield given as percent de;
参考文献
European Journal of Organic Chemistry, , # 34 p. 6034 - 6042
