1-氯甲基-3-三氟甲基苯合成路线 （共 50 条）
反应条件
copper(I) bromide in water
T=20°C; 0.416667 h; under air;
参考文献
Shekarriz, Marzieh; Adib, Mehdi; Biabani, Tayebe; Taghipoor, Sohrab
Journal of Chemical Research, 2012 , vol. 36, # 1 p. 29 - 30
反应条件
in acetonitrile
Irradiation254 nm; Quantum yield;
参考文献
Cristol, Stanley J.; Bindel, Thomas H.
Journal of Organic Chemistry, 1980 , vol. 45, # 6 p. 951 - 957
反应条件
acetone
42 h; Irradiation300 nm; Quantum yield;
参考文献
Cristol, Stanley J.; Bindel, Thomas H.
Journal of Organic Chemistry, 1980 , vol. 45, # 6 p. 951 - 957
反应条件
in ethanol
4 h; Heating;
参考文献
Beattie; Crossley; Dickinson; Dover
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 3 p. 277 - 285
反应条件
1: Cs2CO3; KI / various solvent(s) / 5 h / 100 °C
2: PhI(CF3CO2)2 / acetonitrile; H2O / 65 °C
View Scheme
参考文献
Shum; Peet; Weintraub; Le; Zhao; Barbone; Cashman; Tsay; Dwyer; Loos; Powers; Kropp; Wright; Bitonti; Dumont; Borcherding
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 4-7 p. 1067 - 1078
反应条件
in dimethyl sulfoxide
T=25°C; 0.5 h; Rate constant;
参考文献
Bordwell, Frederick G.; Hughes, David L.
Journal of the American Chemical Society, 1984 , vol. 106, # 11 p. 3234 - 3240
反应条件
potassium carbonate in xylene
1 h; Heating;
参考文献
Scotto di Tella; Dessaigne; Boyer; et al.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 131 - 135
参考文献
Frost
Journal of the American Chemical Society, 1956 , vol. 78, p. 3855
反应条件
sodium hydrogencarbonate; copper(I) bromide in dimethyl sulfoxide
T=120°C; 24 h;
参考文献
Qiu, Dezhi; Wei, Haidong; Zhou, Lihong; Zeng, Qingle
Applied Organometallic Chemistry, 2014 , vol. 28, # 2 p. 109 - 112
反应条件
sodium azide in water; dimethyl sulfoxide
T=50°C; 2 h;
参考文献
LIFE and BRAIN GMBH; MUeLLER, Christa; ZIMMER, Andreas; LABS, Stefanie; BUCHHOLZ, Stephanie; HINZ, Sonja
Patent: WO2012/76974 A1, 2012 ;
Location in patent: Page/Page column 38 ;
