1-氯甲基-3-三氟甲基苯合成路线 （共 50 条）
反应条件
potassium iodide in methanol
参考文献
Lednicer; Emmert
Journal of medicinal chemistry, 1968 , vol. 11, # 6 p. 1258 - 1262
参考文献
Lambert,J.B. et al.
Journal of the American Chemical Society, 1977 , vol. 99, # 9 p. 3059 - 3067
反应条件
1: ethanol / 3 h / Heating 2: 10 N aq. NaOH / 0.33 h / 70 °C View Scheme
参考文献
Brown, Thomas J.; Chapman, Robert F.; Cook, David C.; Hart, Terance W.; McLay, Iain M.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 20 p. 3613 - 3624
反应条件
1: NaOH / dimethylsulfoxide / 15 h / 60 °C 2: conc. HCl / methanol / 24 h View Scheme
参考文献
Jensen; Ager; Bliss; Canfield; Kotecka; Rieckmann; Terpinski; Jacobus
Journal of Medicinal Chemistry, 2001 , vol. 44, # 23 p. 3925 - 3931
反应条件
in diethyl ether Condensation; 16 h; Heating;
参考文献
Newcomb; Choi; Toy
Canadian Journal of Chemistry, 1999 , vol. 77, # 5-6 p. 1123 - 1135
反应条件
(i) Mg, Et2O, (ii) /BRN= 743242/; Multistep reaction;
参考文献
Lednicer; Emmert
Journal of medicinal chemistry, 1968 , vol. 11, # 6 p. 1258 - 1262
反应条件
1: 90 percent / toluene / 6 h / Heating
2: 1. NaH / diethyl ether / 1.) two days, ultrasonic bath, 2.) 10-15 min.
View Scheme
参考文献
Rafizadeh, Karim; Yates, Keith
Journal of Organic Chemistry, 1984 , vol. 49, # 9 p. 1500 - 1506
反应条件
potassium carbonate in xylene
1 h; Heating;
参考文献
Scotto di Tella; Dessaigne; Boyer; et al.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 131 - 135
反应条件
nickel in ethylene glycol dimethyl ether
T=85°C; 0.75 h;
参考文献
Inaba, Shin-ichi; Rieke, Reuben D.
Chemistry Letters, 1984 , p. 25 - 28
反应条件
nickel in ethylene glycol dimethyl ether
6 h; Ambient temperature;
参考文献
Inaba, Shin-ichi; Matsumoto, Hideyuki; Rieke, Reuben D.
Journal of Organic Chemistry, 1984 , vol. 49, # 12 p. 2093 - 2098
