4-苯甲氧基吲哚-3-甲醛合成路线 （共 9 条）
反应条件
copper(l) iodide; potassium hydride in N,N-dimethyl-formamide T=120 - 130°C; 1 h;
参考文献
Yamada, Fumio; Tamura, Mayumi; Somei, Masanori
Heterocycles, 1998 , vol. 49, # 1 p. 451 - 457
反应条件
trichlorophosphate T=10 - 35°C; Vilsmeier-Haack Formylation; 0.75 h; Inert atmosphere;
参考文献
Yanovsky, Inessa; Finkin-Groner, Efrat; Zaikin, Andrey; Lerman, Lena; Shalom, Hila; Zeeli, Shani; Weill, Tehilla; Ginsburg, Isaac; Nudelman, Abraham; Weinstock, Marta
Journal of Medicinal Chemistry, 2012 , vol. 55, # 23 p. 10700 - 10715
反应条件
1: 1.) Tl(OCOCF3)3; 2.) I2, CuI / 1.) TFA, r.t., 24 h; 2.) DMF, r.t., 1 h 2: 70 percent / KH, CuI / dimethylformamide / 1 h / 120 - 130 °C View Scheme
参考文献
Heterocycles, , vol. 49, # 1 p. 451 - 457
反应条件
Yield given. Multistep reaction;
参考文献
Heterocycles, , vol. 22, # 4 p. 797 - 801
反应条件
1: 76 percent / H2 / 10 percent Pd/C / methanol / 1 h / 20 °C 2: 97 percent / DMAP; Et3N / CH2Cl2 / 2 h / 20 °C View Scheme
参考文献
Yamada, Fumio; Tamura, Mayumi; Hasegawa, Atsuko; Somei, Masanori
Chemical and pharmaceutical bulletin, 2002 , vol. 50, # 1 p. 92 - 99
反应条件
hydrogen; palladium on activated charcoal in methanol T=20°C; 1 h;
参考文献
Yamada, Fumio; Tamura, Mayumi; Hasegawa, Atsuko; Somei, Masanori
Chemical and pharmaceutical bulletin, 2002 , vol. 50, # 1 p. 92 - 99
反应条件
sodium tetrahydroborate in methanol; formamide T=100°C; 5 h;
参考文献
Heterocycles, , vol. 47, # 1 p. 509 - 516
反应条件
sodium tetrahydroborate in methanol; formamide
参考文献
Kwon, Tae Hoon; Yoon, Ik Hwan; Shin, Ji-Sun; Lee, Young Hun; Kwon, Bong Jin; Lee, Kyung-Tae; Lee, Yong Sup
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 9 p. 2571 - 2574
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C; 36 h;
参考文献
SANOFI-AVENTIS DEUTSCHLAND GMBH
Patent: WO2007/241 A1, 2007 ;
Location in patent: Page/Page column 24 ;
WO 2007/000241 A1
