4-氯-2-氯甲基-1-甲氧基苯合成路线 （共 9 条）
反应条件
1: 93 percent / ethanol; H2O / 6 h / Heating 2: 70 percent / aq. sulfuric acid / 2 h / Heating 3: 64 percent / 48 percent hydrobromic acid / 24 h / Heating View Scheme
参考文献
Julia; Baillarge
Bulletin de la Societe Chimique de France, 1953 , p. 640,643
反应条件
1: (5-chloro-2-methoxyphenyl)methanol With thionyl chloride in dichloromethane 3 h; Heating / reflux; 2: potassium cyanide; 4-chloro-2-chloromethyl-1-methoxy-benzene With 18-crown-6 ether in acetonitrile T=20°C; 12 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2004/9550 A1, 2004 ;
Location in patent: Page 42 ;
WO 2004/009550 A1
反应条件
in ethanol; water 6 h; Heating;
参考文献
Verhe; De Kimpe; De Buyck; et al.
Bulletin des Societes Chimiques Belges, 1980 , vol. 89, # 6 p. 459 - 485
参考文献
Pfizer Inc
Patent: US2004/92529 A1, 2004 ;
US 20040092529 A1
反应条件
sodium iodide in acetone Heating;
参考文献
Julia,M.; Gaston-Breton,H.
Bulletin de la Societe Chimique de France, 1966 , p. 1335 - 1342
反应条件
1: 93 percent / ethanol; H2O / 6 h / Heating 2: 70 percent / aq. sulfuric acid / 2 h / Heating View Scheme
参考文献
Julia,M.; Gaston-Breton,H.
Bulletin de la Societe Chimique de France, 1966 , p. 1335 - 1342
反应条件
thionyl chloride in dichloromethane
T=0 - 20°C; 16.1667 h;
参考文献
Ackermann, Jean; Bleicher, Konrad; Ceccarelli, Simona M.; Chomienne, Odile; Mattei, Patrizio
Patent: US2008/103182 A1, 2008 ;
Location in patent: Page/Page column 21 ;
反应条件
thionyl chloride in toluene
参考文献
Hoechst Marion Roussel, Inc.
Patent: US6004977 A1, 1999 ;
反应条件
hydrogenchloride; zinc(II) chloride
T=70°C; 2 h;
参考文献
Verhe; De Kimpe; De Buyck; et al.
Bulletin des Societes Chimiques Belges, 1980 , vol. 89, # 6 p. 459 - 485
