alpha-(4-溴苯基)-alpha-乙烯基吡啶-3-甲醇合成路线 （共 8 条）
反应条件
1: PCl5 / CH2Cl2 / 1 h / Ambient temperature 2: CH2Cl2 / 1 h / Ambient temperature View Scheme
参考文献
Baeckvall, Jan-E.; Nordberg, Ruth E.; Nystroem, Jan-E.; Hoegberg, Thomas; Ulff, Bengt
Journal of Organic Chemistry, 1981 , vol. 46, # 17 p. 3479 - 3483
反应条件
magnesium in tetrahydrofuran
参考文献
Astra Lakemedel AB
Patent: US4216328 A1, 1980 ;
反应条件
in tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; toluene
参考文献
Astra Lakemedel AB
Patent: US4216328 A1, 1980 ;
反应条件
magnesium
1.) THF, reflux, 1 h, 2.) THF, room temp., 2 h; Yield given. Multistep reaction;
参考文献
Baeckvall, Jan-E.; Nordberg, Ruth E.; Nystroem, Jan-E.; Hoegberg, Thomas; Ulff, Bengt
Journal of Organic Chemistry, 1981 , vol. 46, # 17 p. 3479 - 3483
反应条件
1: 52 percent / Friedel-Crafts acylation
2: 1.) Mg / 1.) THF, reflux, 1 h, 2.) THF, room temp., 2 h
View Scheme
参考文献
Baeckvall, Jan-E.; Nordberg, Ruth E.; Nystroem, Jan-E.; Hoegberg, Thomas; Ulff, Bengt
Journal of Organic Chemistry, 1981 , vol. 46, # 17 p. 3479 - 3483
反应条件
1: 52 percent / Friedel-Crafts acylation
2: 1.) Mg / 1.) THF, reflux, 1 h, 2.) THF, room temp., 2 h
View Scheme
参考文献
Baeckvall, Jan-E.; Nordberg, Ruth E.; Nystroem, Jan-E.; Hoegberg, Thomas; Ulff, Bengt
Journal of Organic Chemistry, 1981 , vol. 46, # 17 p. 3479 - 3483
反应条件
1: 30 percent / conc. H2SO4 / H2O / 3 h / Heating
2: 86 percent / MnO2 / CHCl3 / 3 h / Ambient temperature
View Scheme
参考文献
Lundstrom; Hogberg; Gosztonyi; De Paulis
Arzneimittel-Forschung/Drug Research, 1981 , vol. 31, # 3 p. 486 - 494
反应条件
1: PCl5 / CH2Cl2
2: 41 percent / dimethylformamide / 3 h / 80 °C
3: 1.25 g / H2NNH2*H2O / methanol / 5 h / 60 °C
View Scheme
参考文献
Carnmalm; De Paulis; Hogberg; et al.
1982 , vol. 36, # 2 B p. 91 - 99
