1,3-二氮杂螺[4,5]癸烷-2,4-二酮合成路线 （共 35 条）
反应条件
iron(II,III) oxide in neat (no solvent) T=70°C; Bucherer-Bergs Reaction; 0.416667 h;
参考文献
Safari, Javad; Javadian, Leila
Comptes Rendus Chimie, 2013 , vol. 16, # 12 p. 1165 - 1171
反应条件
(NH4)2CO3 in ethanol T=55 - 75°C; 24 h;
参考文献
Sarges; Schnur; Belletire; Peterson
Journal of Medicinal Chemistry, 1988 , vol. 31, # 1 p. 230 - 243
反应条件
lithium hydroxide in tetrahydrofuran T=0 - 20°C; 3 h;
参考文献
Nabil Aboul-Enein; El-Azzounya; Maklad; Attia; Wiese
Scientia Pharmaceutica, 2001 , vol. 69, # 4 p. 329 - 350
反应条件
(NH4)2CO3 in methanol; water T=120°C; 0.133333 h; Sealed vialMicrowave irradiation;
参考文献
Rivero, Ignacio A.; Reynoso-Soto, Edgar A.; Ochoa-Teran, Adrian
Arkivoc, 2011 , vol. 2011, # 2 p. 260 - 271
反应条件
in ethanol; water 6 h; Heating;
参考文献
Tsang, Joseph W.; Schmied, Bernhard; Nyfeler, Rolf; Goodman, Murray
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1663 - 1668
反应条件
in ethanol; water T=65°C; 5 h;
参考文献
Salazar, L.; Espada, M.; Pedregal, C.; Florencio, F.; Blanco, S. Garcia
Journal of Molecular Structure, 1985 , vol. 129, p. 321 - 332
反应条件
ammonium hydroxide in ethanol; water Bucherer-Lieb reaction; 6 h; Reflux;
参考文献
Naydenova, Emilia D.; Todorov, Petar T.; Troev, Kolio D.
Phosphorus, Sulfur and Silicon and the Related Elements, 2010 , vol. 185, # 7 p. 1315 - 1320
参考文献
Journal of the American Chemical Society, , vol. 54, p. 2463,2467
反应条件
hydrogenchloride; acetic acid 5 h; Heating;
参考文献
Nabil Aboul-Enein; El-Azzounya; Maklad; Attia; Wiese
Scientia Pharmaceutica, 2001 , vol. 69, # 4 p. 329 - 350
反应条件
1: hydrogen chloride gas / Heating 2: CHCl3 / 3 h / 0 - 20 °C 3: 71 percent / tetrahydrofuran / 3 h / 0 - 20 °C 4: 85 percent / concd. HCl; glacial acetic acid / 5 h / Heating View Scheme
参考文献
Scientia Pharmaceutica, , vol. 69, # 4 p. 329 - 350
