2-溴-4-氟-1-硝基苯合成路线 （共 18 条）
反应条件
N-bromosuccinmide in dichloromethane T=0 - 20°C;
参考文献
Kuntz, Kevin; Uehling, David Edward; Waterson, Alex Gregory; Emmitte, Kyle Allen; Stevens, Kirk; Shotwell, John Brad; Smith, Stephon Cornell; Nailor, Kristen E.; Salovich, James M.; Wilson, Brian John; Cheung, Mui; Mook, Robert Anthony; Baum, Erich W.; Moorthy, Ganesh
Patent: US2008/300242 A1, 2008 ;
Location in patent: Page/Page column 62 ;
US 20080300242 A1
反应条件
dihydrogen peroxide; trifluoroacetic anhydride in dichloromethane 1 h; Heating;
参考文献
Beugelmans, Rene; Chbani, Mohamed
Bulletin de la Societe Chimique de France, 1995 , vol. 132, p. 306 - 313
反应条件
sulfuric acid; water; nitric acid T=0°C;
参考文献
Schlosser, Manfred; Ginanneschi, Assunta; Leroux, Frederic
European Journal of Organic Chemistry, 2006 , # 13 p. 2956 - 2969
反应条件
sodium nitrate; methanesulfonic acid T=20 - 30°C;
参考文献
US2010/280268 A1, ;
Page/Page column 22 ;
反应条件
copper(ll) bromide in acetonitrile 3.5 h; Reflux;
参考文献
WO2014/12360 A1, ;
Paragraph 00424 ;
反应条件
in tetrahydrofuran T=-40°C;
参考文献
Schlosser, Manfred; Ginanneschi, Assunta; Leroux, Frederic
European Journal of Organic Chemistry, 2006 , # 13 p. 2956 - 2969
反应条件
1: 57 percent / tetrahydrofuran / -40 °C 2: 48 percent / BuLi / tetrahydrofuran; hexane / -75 °C View Scheme
参考文献
Schlosser, Manfred; Ginanneschi, Assunta; Leroux, Frederic
European Journal of Organic Chemistry, 2006 , # 13 p. 2956 - 2969
反应条件
sulfuric acid; nitric acid in water T=60°C; 0.5 h;
参考文献
Wang, Ming-Zhong; Xu, Han; Feng, Qi; Wang, L.I.-Zhong; Wang, S.U.-Hua; Li, Zheng-Ming
Journal of Agricultural and Food Chemistry, 2009 , vol. 57, # 17 p. 7912 - 7918
反应条件
1.1: 57 percent / tetrahydrofuran / -40 °C 2.1: sec-butyllithium / cyclohexane; tetrahydrofuran / -75 °C 2.2: 54 percent / cyclohexane; tetrahydrofuran / cooling View Scheme
参考文献
Schlosser, Manfred; Ginanneschi, Assunta; Leroux, Frederic
European Journal of Organic Chemistry, 2006 , # 13 p. 2956 - 2969
反应条件
in tetrahydrofuran T=-50°C; 1 h;
参考文献
Zegar, Siead; Tokar, Christopher; Enache, Livia A.; Rajagopol, Venkat; Zeller, Wayne; O'Connell, Matthew; Singh, Jasbir; Muellner, Frank W.; Zembower, David E.
Organic Process Research and Development, 2007 , vol. 11, # 4 p. 747 - 753
