1,3-二氮杂螺[4.4]壬烷-2,4-二酮合成路线 （共 19 条）
反应条件
(NH4)2CO3 in ethanol; water T=58 - 60°C; 2 h;
参考文献
Ho, Bin; Michael Crider; Stables, James P
European Journal of Medicinal Chemistry, 2001 , vol. 36, # 3 p. 265 - 286
反应条件
sodium cyanide; (NH4)2CO3 in ethanol; water T=60°C; 5 h;
参考文献
Moloney, Gerard P.; Martin, Graeme R.; Mathews, Neil; Milne, Aynsley; Hobbs, Heather; Dodsworth, Susan; Sang, Pang Yih; Knight, Cameron; Williams, Marnie; Maxwell, Miles; Glen, Robert C.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 14 p. 2504 - 2526
反应条件
(NH4)2CO3 in methanol; water T=140°C; 0.133333 h; Sealed vialMicrowave irradiation;
参考文献
Rivero, Ignacio A.; Reynoso-Soto, Edgar A.; Ochoa-Teran, Adrian
Arkivoc, 2011 , vol. 2011, # 2 p. 260 - 271
反应条件
in ethanol Bucherer-Lieb reaction; 6 h; Heating;
参考文献
Naydenova, Emilia; Pencheva, Nevena; Popova, Julita; Stoyanov, Neyko; Lazarova, Maria; Aleksiev, Boris
Farmaco, 2002 , vol. 57, # 3 p. 189 - 194
反应条件
ammonium hydroxide in ethanol; water Bucherer-Lieb reaction; 6 h; Reflux;
参考文献
Naydenova, Emilia D.; Todorov, Petar T.; Troev, Kolio D.
Phosphorus, Sulfur and Silicon and the Related Elements, 2010 , vol. 185, # 7 p. 1315 - 1320
参考文献
Journal of the American Chemical Society, , vol. 64, p. 522
Bulletin de la Societe Chimique de France, , p. 445,448
反应条件
in ethanol; water T=45°C; 3.5 h; ultrasonication: other temperature, reaction time, absence of ultrasonication); Product distribution;
参考文献
Li, Jital; Li, Lijun; Li, Tongshuang; Waog, Jianzhong
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1998 , vol. 37, # 3 p. 298 - 300
反应条件
ammonium hydroxide in ethanol Bucherer-Lieb reaction; 6 h;
参考文献
European Journal of Medicinal Chemistry, , vol. 43, # 6 p. 1199 - 1205
反应条件
1: cyclopentanone With Na2S2O5 2: potassium cyanide Bucherer-Bergs reaction; 3: (NH4)2CO3 Bucherer-Bergs reaction;
参考文献
Bulletin of the Chemical Society of Ethiopia, , vol. 24, # 1 p. 77 - 83
反应条件
1: 71 percent / Ba(OH)2*8H2O / H2O / 3 h / Heating 2: 39 percent / aq. NaOH / 2-methyl-propan-2-ol View Scheme
参考文献
Ho, Bin; Michael Crider; Stables, James P
European Journal of Medicinal Chemistry, 2001 , vol. 36, # 3 p. 265 - 286
