二(alpha-氯乙基)醚合成路线 （共 12 条）
反应条件
sodium hydroxide; N-ethyl-N,N-diisopropylamine in methanol; dichloromethane; water
参考文献
Terumo Kabushiki Kaisha
Patent: US5155106 A1, 1992 ;
反应条件
potassium cyanide; sodium hydroxide; formaldehyd; NaH; acetic acid; dimethyl amine in tetrahydrofuran; ethanol; hexane; water; ethyl acetate; N,N-dimethyl-formamide
参考文献
Pfizer Inc.
Patent: US5227397 A1, 1993 ;
参考文献
Geuther; Laatsch
Justus Liebigs Annalen der Chemie, 1883 , vol. 218, p. 13
参考文献
Kessel
Justus Liebigs Annalen der Chemie, 1875 , vol. 175, p. 50
参考文献
Halbrook, James; Kesicki, Edward A.; Burgess, Laurence E.; Schlachter, Stephen T.; Eary, Charles T.; Schiro, Justin G; Huang, Hongmei; Evans, Michael; Han, Yongxin
Patent: US2002/165218 A1, 2002 ;
US 20020165218 A1
反应条件
sodium chloride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; water
参考文献
ONO Pharmaceutical Co., Ltd.
Patent: US6506757 B1, 2003 ;
参考文献
Geuther; Laatsch
Justus Liebigs Annalen der Chemie, 1883 , vol. 218, p. 13
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Hanriot
Annales de Chimie (Cachan, France), vol. 25, p. 221
参考文献
Geuther; Laatsch
Justus Liebigs Annalen der Chemie, 1883 , vol. 218, p. 13
反应条件
potassium carbonate in water; N,N-dimethyl-formamide
参考文献
Takeda Chemical Industries, Ltd.
Patent: US6235771 B1, 2001 ;
反应条件
hydrogenchloride; Hg; sodium in ethanol
参考文献
Bencherif; Merouane; Lippiello; Patrick M.; Caldwell; William S.
Patent: US5510355 A1, 1996 ;
