1,2,4-三偶氮[4,3]吡啶酮合成路线 （共 12 条）
反应条件
sulfuric acid in 2-ethoxy-ethanol 24 h; Reflux;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2009/209550 A1, 2009 ;
Location in patent: Page/Page column 25-26 ;
反应条件
trifluorormethanesulfonic acid in toluene T=150°C; 0.25 h; Microwave irradiation;
参考文献
Rombouts, Frederik; Franken, Dennis; Martinez-Lamenca, Carolina; Braeken, Mirielle; Zavattaro, Chiara; Chen, Jinsheng; Trabanco, Andres A.
Tetrahedron Letters, 2010 , vol. 51, # 37 p. 4815 - 4818
反应条件
sulfuric acid in 2-ethoxy-ethanol; water
反应条件
T=200°C; Cyclization; 2 h;
参考文献
Sakai, Norio; Funabashi, Makoto; Minakata, Satoshi; Ryu, Ilhyong; Komatsu, Mitsuo
Heterocycles, 2000 , vol. 53, # 2 p. 265 - 270
反应条件
1: 100 percent / NH2NH2 / 2 h / 100 °C 2: 57 percent / 2 h / 200 °C View Scheme
参考文献
Heterocycles, , vol. 53, # 2 p. 265 - 270
反应条件
water T=25°C; Rate constant;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 56, # 10 p. 2969 - 2973
反应条件
in tetrahydrofuran T=25°C; Rate constant;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 56, # 10 p. 2969 - 2973
反应条件
1: 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one With sodium hydride in DMF (N,N-dimethyl-formamide) 0.5 h; 2: 3-chloropropyl tosylate in DMF (N,N-dimethyl-formamide) T=50°C; 4 h;
参考文献
Wyeth
Patent: US2004/204402 A1, 2004 ;
Location in patent: Page/Page column 12-13 ;
US 20040204402 A1
反应条件
potassium carbonate in acetonitrile 8 h; Heating / reflux;
参考文献
Hypnion, Inc.
Patent: US2003/232839 A1, 2003 ;
Location in patent: Page 24; 26 ;
反应条件
sodium hydride 1.) xylene, reflux, 1 h, 2.) xylene, 150 deg C, 20 h; Yield given. Multistep reaction;
参考文献
Alhaider
Journal of Pharmaceutical Sciences, 1992 , vol. 81, # 1 p. 99 - 103
