2,5-二甲氧基四氢呋喃合成路线 （共 286 条）
反应条件
MgI2 etherate in acetonitrile T=80°C; Clauson-Kaas pyrrole synthesis; 10 h; chemoselective reaction;
参考文献
Zhang, Xingxian; Shi, Junchen
Tetrahedron, 2011 , vol. 67, # 5 p. 898 - 903
反应条件
acetic acid 1 h; Reflux;
参考文献
Asian Journal of Chemistry, , vol. 25, # 1 p. 501 - 504
反应条件
1: 2,5-dimethoxy-tetrahydrofuran With hydrogenchloride; water T=70°C; 1 h; 2: acetone-1,3-dicarboxylic acid; benzylamine With hydrogenchloride; sodium acetate in water T=0 - 20°C;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/84300 A1, 2008 ;
Location in patent: Page/Page column 100-101 ;
WO 2008/084300 A1
反应条件
1: 2,5-dimethoxy-tetrahydrofuran With hydrogenchloride in water T=0°C; 2: acetone-1,3-dicarboxylic acid; [14C]-N-Benzylamine hydrochloride With sodium acetate in water T=0 - 50°C; 3.66667 h; 3: With sodium hydroxide in water T=0°C; pH=10;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2004/9588 A1, 2004 ;
Location in patent: Page 63 ;
WO 2004/009588 A1
反应条件
sodium acetate in hydrogenchloride
参考文献
Pfizer Inc.
Patent: US2004/14742 A1, 2004 ;
Location in patent: Page 31 ;
US 20040014742 A1
反应条件
hydrogenchloride; sodium hydroxide; sulfuric acid; sodium acetate
参考文献
Nippon Shinyaku Co., Ltd.
Patent: EP1243268 A1, 2002 ;
参考文献
Pfizer Inc.
Patent: US5859011 A1, 1999 ;
反应条件
T=110 - 120°C; 4.5 h; Neat (no solvent);
参考文献
Ramesh, Katla; Murthy, Sabbavarapu Narayana; Nageswar, Yadavalli Venkata Durga
Synthetic Communications, 2012 , vol. 42, # 16 p. 2471 - 2477
反应条件
in water; benzene Heating;
参考文献
Kashima, Choji; Hibi, Shigeki; Maruyama, Tatsuya; Harada, Kazuo; Omote, Yoshimori
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 913 - 916
反应条件
phosphorus pentoxide in toluene T=110°C; 0.333333 h;
参考文献
Fang; Leysen; Ottenheijm
Synthetic Communications, 1995 , vol. 25, # 12 p. 1857 - 1861
