2-(4-硝基苯基)-3H-苯并咪唑-5-羧酸合成路线 （共 9 条）
反应条件
MCM-41-SO3H mesoporous nanoparticles in water
T=20°C; 0.5 h; chemoselective reaction;
参考文献
Mahdavinia, Gholam Hossein; Rostamizadeh, Shahnaz; Amani, Ali Mohammad; Sepehrian, Hamid
Heterocyclic Communications, 2012 , vol. 18, # 1 p. 33 - 37
反应条件
sodium hydroxide in methanol; water
参考文献
Mitsui Chemicals, Inc.
Patent: US5821258 A1, 1998 ;
反应条件
in nitrobenzene; N,N-dimethyl-formamide
参考文献
Avanir Pharmaceuticals
Patent: US6759425 B2, 2004 ;
反应条件
1: Na2S2O5 / ethanol; water / 0 - 20 °C
2: N,N-dimethyl-formamide / 6 h / 130 °C
View Scheme
参考文献
Qi, Yunkun; Ma, Ruixin; Li, Xin; Hu, Yue; Ma, Siti; Cong, Chao; Ma, Xiaodong; Cui, Wenping; Ma, Shutao
Letters in Drug Design and Discovery, 2011 , vol. 8, # 10 p. 966 - 971
反应条件
in N,N-dimethyl-formamide
T=130°C; 6 h;
参考文献
Qi, Yunkun; Ma, Ruixin; Li, Xin; Hu, Yue; Ma, Siti; Cong, Chao; Ma, Xiaodong; Cui, Wenping; Ma, Shutao
Letters in Drug Design and Discovery, 2011 , vol. 8, # 10 p. 966 - 971
反应条件
[Pro]NO3
0.333333 h;
参考文献
Rostamizadeh, Shahnaz; Aryan, Reza; Ghaieni, Hamid Reza; Amani, Ali Mohammad
Journal of Heterocyclic Chemistry, 2009 , vol. 46, # 1 p. 74 - 78
反应条件
1: 2-(4-nitrophenyl)-1H-benzimidazole-5-carboxylic acid in N,N-dimethyl-formamide
3 h;
2: aniline With 4-(N,N-dimethlyamino)pyridine in N,N-dimethyl-formamide
18 h;
参考文献
Richards, Mark L.; Lio, Shirley Cruz; Sinha, Anjana; Tieu, Kenneth K.; Sircar, Jagadish C.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 26 p. 6451 - 6454
反应条件
1: 2-(4-nitrophenyl)-1H-benzimidazole-5-carboxylic acid With 1,1'-carbonyldiimidazole in N,N-dimethyl-formamide
T=80°C; 3 h;
2: benzoyl chloride in N,N-dimethyl-formamide
18 h; Heating;
参考文献
Richards, Mark L.; Lio, Shirley Cruz; Sinha, Anjana; Banie, Homayon; Thomas, Richard J.; Major, Michael; Tanji, Mark; Sircar, Jagadish C.
European Journal of Medicinal Chemistry, 2006 , vol. 41, # 8 p. 950 - 969
反应条件
1.1: 1,1'-carbonyldiimidazole / dimethylformamide / 3 h / 80 °C
1.2: dimethylformamide / 18 h / Heating
2.1: H2 / Pd/C / ethanol; dimethylformamide / 6 h / 70 - 90 °C
View Scheme
参考文献
Richards, Mark L.; Lio, Shirley Cruz; Sinha, Anjana; Tieu, Kenneth K.; Sircar, Jagadish C.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 26 p. 6451 - 6454
