2-氨基-4-甲基吡啶合成路线 （共 193 条）
反应条件
di-tert-butyl dicarbonate in tert-butyl alcohol T=23°C;
参考文献
SCHERING CORPORATION
Patent: WO2003/103669 A1, 2003 ;
Location in patent: Page 20 ;
WO 03/103669 A1
反应条件
zinc(II) chloride in dichloromethane T=20°C; 0.333333 h;
参考文献
Arifuddin, M.; Lakshmikant, N.; Rajasekar, N.; Shinde, D. B.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 2012 , vol. 51, # 8 p. 1168 - 1172,5
反应条件
in tert-butyl alcohol T=30°C;
参考文献
Pharmacia Corporation
Patent: US6664255 B1, 2003 ;
Location in patent: Page column 104; 105 ;
US 6664255 B1
反应条件
1: With 1,3-dibromo-5,5-dimethyl-hydantoin in dichloromethane T=-45°C; 0.5 h; 2: With sodium hydrogencarbonate in dichloromethane; water T=-45 - 22°C;
参考文献
Wu, Runzhi; Smidansky, Eric D.; Oh, Hyung Suk; Takhampunya, Ratree; Padmanabhan, Radhakrishnan; Cameron, Craig E.; Peterson, Blake R.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 22 p. 7958 - 7966
反应条件
bromine in acetic acid T=20°C; 1 h;
参考文献
Lindstroem, Stefan; Ahmad, Tania; Grivas, Spiros
Heterocycles, 1994 , vol. 38, # 3 p. 529 - 540
反应条件
hydrogen bromide; dihydrogen peroxide T=70°C; 1 h; Product distribution;
参考文献
Journal fuer Praktische Chemie (Leipzig), , vol. 331, # 3 p. 369 - 374
反应条件
sodium hydrogencarbonate in water 72 h; Ambient temperature;
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 23 p. 4415 - 4424
反应条件
sodium carbonate in 1,4-dioxane; water Cyclization; Tschitschibabin reaction; 22 h; Heating;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 72, # 6 p. 1327 - 1334
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 14 p. 2856 - 2859
反应条件
1.1: nitric acid; sulfuric acid / 22 h / 0 - 100 °C 1.2: 20 °C / pH 4 - 5 2.1: copper dichloride / N,N-dimethyl-formamide / 16.5 h / 60 - 110 °C 3.1: potassium ethanolate / diethyl ether / 16 h 4.1: iron / acetic acid / 6 h / 60 °C View Scheme
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2005/97129 A2, 2005 ;
WO 2005/097129 A2
