2-氨基-4-甲基吡啶合成路线 （共 193 条）
反应条件
in ethylene glycol dimethyl ether 36 h; Reflux;
参考文献
Moraski, Garrett C.; Oliver, Allen G.; Markley, Lowell D.; Cho, Sanghyun; Franzblau, Scott G.; Miller, Marvin J.
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 15 p. 3493 - 3498
反应条件
aluminum oxide 0.0166667 h; Microwave irradiationneat (no solvent);
参考文献
Chunavala, Kaushik C.; Joshi, Girdhar; Suresh, Eringathodi; Adimurthy, Subbarayappa
Synthesis, 2011 , # 4 art. no. Z27510SS, p. 635 - 641
反应条件
8 h; Heating / reflux;
参考文献
GRUeNENTHAL GMBH
Patent: WO2004/33453 A1, 2004 ;
Location in patent: Page/Page column 26 ;
反应条件
1: With sulfuric acid; nitric acid T=0 - 50°C; 24 h; 2: in water pH=7; Cooling with ice;
参考文献
Beijing Yiling Bioengineering Co., Ltd.
Patent: EP2366691 A1, 2011 ;
Location in patent: Page/Page column 12-13 ;
反应条件
sulfuric acid; nitric acid T=0 - 70°C; 4 h;
参考文献
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, , vol. 96, p. 952 - 962
反应条件
1: With sulfuric acid; nitric acid 2: With hydrogenchloride; sodium nitrite
参考文献
Timperley, Christopher M.; Banks, R. Eric; Young, Ian M.; Haszeldine, Robert N.
Journal of Fluorine Chemistry, 2011 , vol. 132, # 8 p. 541 - 547
反应条件
1.1: nitric acid; sulfuric acid / 24 h / 0 - 50 °C 1.2: pH 7 / Cooling with ice 2.1: water; sodium nitrite; sulfuric acid / 0 °C / Reflux View Scheme
参考文献
Beijing Yiling Bioengineering Co., Ltd.
Patent: EP2366691 A1, 2011 ;
反应条件
1: CHCl3 / 2 h / Ambient temperature 2: ascorbic acid View Scheme
参考文献
Marchi, Egidio; Montecchi, Laura; Venturini, Anna Paola; Mascellani, Giuseppe; Brufani, Mario; Cellai, Luciano
Journal of Medicinal Chemistry, 1985 , vol. 28, # 7 p. 960 - 963
反应条件
1.1: sulfuric acid; sodium nitrite / water / 2.25 h / 0 - 95 °C 1.2: 20 °C / pH 6 - 7 2.1: N-bromosuccinmide; acetic acid / ethyl acetate / 0.5 h / 20 °C 2.2: pH 8 View Scheme
参考文献
AB SCIENCE; BENJAHAD, Abdellah; MOUSSY, Alain; CHEVENIER, Emmanuel; PICOUL, Willy; LERMET, Anne; PEZ, Didier; MARTIN, Jason; SANDRINELLI, Franck
Patent: WO2013/14170 A1, 2013 ;
WO 2013/014170 A1
反应条件
in tert-butyl alcohol
参考文献
Ihle; Krause
Journal of Organic Chemistry, 1996 , vol. 61, # 14 p. 4810 - 4811
