2-甲基-1,3-苯并噻唑-6-羧酸合成路线 （共 7 条）
反应条件
hydrogenchloride in ethylene glycol Heating;
参考文献
Nivalkar, Kishor R.; Mashraqui, Sabir H.
Synthetic Communications, 1996 , vol. 26, # 19 p. 3535 - 3542
反应条件
1: With copper(l) iodide; Na2S*9H2O in N,N-dimethyl-formamide T=80°C; 12 h; 2: With hydrogenchloride in N,N-dimethyl-formamide T=20°C;
参考文献
Ma, Dawei; Xue, Peng; Jiang, Yongwen; Xie, Siwei; Zhang, Xiaojing; Dong, Jinhua
Angewandte Chemie, International Edition, 2009 , vol. 48, # 23 p. 4222 - 4225
反应条件
1: 1,3-benzothiazole-6-carboxylic acid With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1 h; 2: methyl iodide in tetrahydrofuran; hexane T=20°C;
参考文献
WO2008/82490 A2, ;
Page/Page column 102; 103 ;
WO 2008/082490 A2
反应条件
sodium acetate in acetic acid
参考文献
J. Gen. Chem. USSR (Engl. Transl.), , vol. 32, # 12 p. 4040 - 4047,3967 - 3972
参考文献
Yakugaku Zasshi, , vol. 78, p. 376,379
Chem.Abstr., , p. 14587
参考文献
Saikachi; Yoshina
Yakugaku Zasshi, 1958 , vol. 78, p. 376,379
Chem.Abstr., 1958 , p. 14587
反应条件
2: N2H4+H2O
View Scheme
参考文献
Saikachi; Yoshina
Yakugaku Zasshi, 1958 , vol. 78, p. 376,379
Chem.Abstr., 1958 , p. 14587
