sodium acetate 5 h; Heating;

1: formic acid methyl ester; chloroacetonitrile With sodium methylate in tetrahydrofuran T=0 - 20°C; 5 h; 2: 2,4-diamino-6(1H)-pyrimidone With sodium acetate in tetrahydrofuran; water 12 h;

暂无反应条件数据

ammonia in 1,4-dioxane T=60°C; 2 h; Yield given;

1: formic acid methyl ester; chloroacetonitrile With sodium methylate in tetrahydrofuran 2: 2,4-diamino-6-hydroxypyrimidine With sodium acetate in tetrahydrofuran; water Further stages.;

1: 75 percent / Na acetamide / 1 h / 120 °C 2: pyridine / 80 °C 3: 74 percent / N-bromosuccinimide, benzoyl peroxide / CCl4 / 0.5 h / Heating 4: NBS, K2CO3, benzoyl peroxide / CCl4 / 4 h / Heating 5: 1) AgCO3; 2) triethylamine / 1) H2O, dioxane, r.t., 48 h; 2) H2O, dioxane, r.t., 36 h 6: 94 percent / K acetate, Pd/C / H2O; methanol 7: 71 percent / chromic anhydride-pyridine complex / 24 h / 40 °C 8: NH2OH / ethanol 9: 1) acetic anhydride, pyridine; 2) conc. ammonia / 2) CH3OH 10: CF3COOH / 2 h / 60 °C 11: cc. NH3 / dioxane / 2 h / 60 °C View Scheme

1: CF3COOH / 2 h / 60 °C 2: cc. NH3 / dioxane / 2 h / 60 °C View Scheme

1: pyridine / 80 °C 2: 74 percent / N-bromosuccinimide, benzoyl peroxide / CCl4 / 0.5 h / Heating 3: NBS, K2CO3, benzoyl peroxide / CCl4 / 4 h / Heating 4: 1) AgCO3; 2) triethylamine / 1) H2O, dioxane, r.t., 48 h; 2) H2O, dioxane, r.t., 36 h 5: 94 percent / K acetate, Pd/C / H2O; methanol 6: 71 percent / chromic anhydride-pyridine complex / 24 h / 40 °C 7: NH2OH / ethanol 8: 1) acetic anhydride, pyridine; 2) conc. ammonia / 2) CH3OH 9: CF3COOH / 2 h / 60 °C 10: cc. NH3 / dioxane / 2 h / 60 °C View Scheme

1: 71 percent / chromic anhydride-pyridine complex / 24 h / 40 °C 2: NH2OH / ethanol 3: 1) acetic anhydride, pyridine; 2) conc. ammonia / 2) CH3OH 4: CF3COOH / 2 h / 60 °C 5: cc. NH3 / dioxane / 2 h / 60 °C View Scheme

1: NH2OH / ethanol 2: 1) acetic anhydride, pyridine; 2) conc. ammonia / 2) CH3OH 3: CF3COOH / 2 h / 60 °C 4: cc. NH3 / dioxane / 2 h / 60 °C View Scheme