6-氨基吡啶-2-羧酸乙酯合成路线 （共 18 条）
反应条件
1: With thionyl chloride T=0°C; Reflux; 2: With sodium carbonate pH=9;
参考文献
SIRTRIS PHARMACEUTICALS, INC.; VU, Chi, B.
Patent: WO2010/19606 A1, 2010 ;
Location in patent: Page/Page column 81-82 ;
WO 2010/019606 A1
反应条件
1: oxalyl chloride / 13 h / 20 - 45 °C 2: 0.50 g / 1 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 56, # 43 p. 8419 - 8427
反应条件
1: 97.9 percent / Et3N / CH2Cl2 / 18 h / Ambient temperature 2: 54.7 percent / aq. KMnO4 / 2 h / 75 °C 3: 88 percent / 10percent aq. NaOH / 2 h / Heating 4: 54.5 percent / HCl / 9 h / Heating View Scheme
参考文献
Journal of Carbohydrate Chemistry, , vol. 13, # 5 p. 715 - 736
反应条件
sulfuric acid 5 h; Inert atmosphereReflux;
参考文献
Frimannsson, Daniel O.; McCabe, Thomas; Schmitt, Wolfgang; Lawler, Mark; Gunnlaugsson, Thorfinnur
Supramolecular Chemistry, 2010 , vol. 22, # 9 p. 483 - 490
参考文献
Farmaco, Edizione Scientifica, , vol. 14, p. 594,596
反应条件
1: 54.7 percent / aq. KMnO4 / 2 h / 75 °C 2: 88 percent / 10percent aq. NaOH / 2 h / Heating 3: 54.5 percent / HCl / 9 h / Heating View Scheme
参考文献
Journal of Carbohydrate Chemistry, , vol. 13, # 5 p. 715 - 736
反应条件
1: 88 percent / 10percent aq. NaOH / 2 h / Heating 2: 54.5 percent / HCl / 9 h / Heating View Scheme
参考文献
Journal of Carbohydrate Chemistry, , vol. 13, # 5 p. 715 - 736
反应条件
sulfuric acid; dihydrogen peroxide; iron(II) sulfate 1.) 0-5 deg C, water; Yield given. Multistep reaction;
参考文献
Chemistry of Heterocyclic Compounds (New York, NY, United States), , vol. 24, # 8 p. 885 - 886
Khimiya Geterotsiklicheskikh Soedinenii, , # 8 p. 1075 - 1077
反应条件
Esterification; 1 h; Heating;
参考文献
Zafar, Abdullah; Geib, Steven J.; Hamuro, Yoshitomo; Carr, Andrew J.; Hamilton, Andrew D.
Tetrahedron, 2000 , vol. 56, # 43 p. 8419 - 8427
反应条件
4-(N,N-dimethlyamino)pyridine in acetone; tert-butyl alcohol T=20°C; 18 h;
参考文献
SIRTRIS PHARMACEUTICALS, INC.; VU, Chi, B.
Patent: WO2010/19606 A1, 2010 ;
Location in patent: Page/Page column 82 ;
WO 2010/019606 A1
