1-甲基环丙烷-1-羧酸合成路线 （共 22 条）
反应条件
1: With methanol; sodium hydroxide; water T=50 - 60°C; 5 h; 2: With hydrogenchloride; water pH=1;
参考文献
ELI LILLY AND COMPANY
Patent: WO2007/53346 A1, 2007 ;
Location in patent: Page/Page column 21 ;
WO 2007/053346 A1
反应条件
potassium hydroxide T=100°C; im Rohr;
参考文献
Monatshefte fuer Chemie, , vol. 42, p. 230
反应条件
sodium hypobromide in water
参考文献
Bulletin de la Societe Chimique de France, , p. 1708 - 1711
反应条件
sodium hydroxide 3 h; Heating;
参考文献
Kostitsyn, A. B.; Ruzek, H.; Heydt, H.; Regitz, M.; Nefedov, O. M.
Russian Chemical Bulletin, 1994 , vol. 43, # 4 p. 635 - 640
Izvestiya Akademi Nauk, Seriya Khimicheskaya, 1994 , # 4 p. 684 - 689
参考文献
Journal of the American Chemical Society, , vol. 108, # 9 p. 2343 - 2348
反应条件
hydrogenchloride; water in 1,4-dioxane T=20°C;
参考文献
Journal of the American Chemical Society, , vol. 133, # 49 p. 19598 - 19601
参考文献
Journal of the American Chemical Society, , vol. 98, p. 2013 - 2014
反应条件
aluminium trichloride in benzene
参考文献
Journal of the Chemical Society [Section] C: Organic, , p. 2548 - 2554
反应条件
in tetrahydrofuran 1.) -20 deg C, 2.) to room temp., 1 h;
参考文献
Jahngen, Edwin G. E.; Phillips, Douglas; Kobelski, Robert J.; Demko, Donald M.
Journal of Organic Chemistry, 1983 , vol. 48, # 15 p. 2472 - 2476
反应条件
lithium diisopropyl amide 1.) THF, 0 deg C, 10 min, 2.) room temperature, 1 h; Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 47, # 5 p. 893 - 895
