N-(2-氯苄基)-2-(2-噻吩)乙胺盐酸盐合成路线 （共 13 条）
反应条件
in dimethyl sulfoxide
参考文献
Parcor
Patent: US4174448 A1, 1979 ;
反应条件
sodium hydroxide; methanesulfonic acid; paraformaldehyde in N-methyl-acetamide; dichloromethane
参考文献
Parcor
Patent: US4174448 A1, 1979 ;
反应条件
1: in N,N-dimethyl-formamide T=0 - 60°C; 2: With hydrogenchloride in ethanol
参考文献
Rege, Chandana M.; Gadre; Bhalekar, Satish M.
Indian Journal of Heterocyclic Chemistry, 2010 , vol. 20, # 2 p. 197 - 198
反应条件
hydrogenchloride; palladium in methanol; di-isopropyl ether
参考文献
Sanofi
Patent: US4873343 A1, 1989 ;
反应条件
nickel monoaluminide
参考文献
Sanofi
Patent: US4873343 A1, 1989 ;
反应条件
1: 100 percent / ethanol / 1 h / Heating
2: 1.)potassium t-butoxide / 1.) THF, 45 deg C, 0.5 h, 2.) 45 deg C, 1 h
3: sodium borohydride / ethanol / 1 h / 50 °C
View Scheme
参考文献
Heymes, A.; Chekroun, I.
Synthesis, 1987 , # 3 p. 245 - 249
反应条件
sodium tetrahydroborate in ethanol
T=50°C; 1 h; Yield given;
参考文献
Heymes, A.; Chekroun, I.
Synthesis, 1987 , # 3 p. 245 - 249
反应条件
1: 100 percent / toluene / 0.5 h / Ambient temperature
2: 80 percent / 50percent aq. NaOH / tetra-n-butylammonium iodide / toluene / 0.5 h / 40 °C
3: sodium borohydride / ethanol / 1 h / 50 °C
View Scheme
参考文献
Heymes, A.; Chekroun, I.
Synthesis, 1987 , # 3 p. 245 - 249
反应条件
1: 80 percent / 50percent aq. NaOH / tetra-n-butylammonium iodide / toluene / 0.5 h / 40 °C
2: sodium borohydride / ethanol / 1 h / 50 °C
View Scheme
参考文献
Heymes, A.; Chekroun, I.
Synthesis, 1987 , # 3 p. 245 - 249
反应条件
sodium tetrahydroborate in methanol
T=0 - 20°C;
参考文献
Rege, Chandana M.; Gadre; Bhalekar, Satish M.
Indian Journal of Heterocyclic Chemistry, 2010 , vol. 20, # 2 p. 197 - 198
