(R)-(+)-2-(Diphenylphosphino)-2′-methoxy-1,1′-binaphthyl; N-ethyl-N,N-diisopropylamine; tris(dibenzylideneacetone)dipalladium(0) chloroform complex in ethanol T=25°C; P=76000 Torr; 4 h;

in tetrahydrofuran; hexane T=25°C; 1 h;

1.1: Zn; TMSCl / dimethylformamide / 0.33 h / 0 °C 1.2: CuCN; LiCl / dimethylformamide / 0.08 h / 0 °C 1.3: 40 percent / dimethylformamide / 16 h / -30 - 20 °C 2.1: 96 percent / H2 / Pd/C / methanol / 24 h View Scheme

(R)-(+)-2-(Diphenylphosphino)-2′-methoxy-1,1′-binaphthyl; N-ethyl-N,N-diisopropylamine; tris(dibenzylideneacetone)dipalladium(0) chloroform complex in ethanol T=25°C; P=76000 Torr; 4 h;