(Z)-2-(2-三苯甲基氨基噻唑-4-基)-2-(2-叔丁氧羰基丙-2-氧亚氨)乙酸合成路线 （共 6 条）
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C;
参考文献
NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD.; BURNS, Christopher, J.; GOSWAMI, Rajesh; JACKSON, Randy, W.; LESSEN, Thomas; LI, Weiping; PEVEAR, Daniel; TIRUNAHARI, Pavan, Kumar; XU, Hongyu
Patent: WO2010/130708 A1, 2010 ;
Location in patent: Page/Page column 108 ;
WO 2010/130708 A1
反应条件
triethylamine in N,N-dimethyl-formamide
反应条件
potassium hydroxide in methanol 2 h; Heating;
参考文献
Bucourt; Heymes; Perronnet; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 4 p. 307 - 316
反应条件
1: 90 percent / potassium carbonate / dimethylformamide / 1.5 h / Ambient temperature 2: 61 percent / potassium hydroxide / methanol / 2 h / Heating View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 16, # 4 p. 307 - 316
反应条件
1: 90 percent / potassium carbonate / dimethylformamide / 1.5 h / Ambient temperature 2: 61 percent / potassium hydroxide / methanol / 2 h / Heating View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 16, # 4 p. 307 - 316
反应条件
1: 82 percent / K2CO3 / dimethylsulfoxide / Ambient temperature; overnight 2: 52 percent / 2N aq. NaOH / methanol / 2 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 21, # 4 p. 1097 - 1111
